AI Article Synopsis

  • * Some drugs like buspirone and spiperone decreased the calling, indicating potential anxiolytic effects, while others like 8-OH-DPAT increased the calling, suggesting anxiogenic effects.
  • * The observed changes in calling were not due to sedation or temperature effects, highlighting ultrasonic calling as a useful method for testing the anxiety-related properties of new drugs.

Article Abstract

The influence of a range of drugs acting at various 5-HT receptor sites on the ultrasonic calling of mouse pups was assessed. Calling was decreased by the novel anxiolytics buspirone, ipsapirone and gepirone, and by TFMPP, spiperone, ritanserin and GR 38032F. In contrast, 8-OH-DPAT, DOI and quipazine increased the rate of calling. These effects on ultrasonic calling were independent of sedative or thermoregulatory actions of these drugs. Present data provide further support for the view that ultrasonic calling can be used to assess novel compounds for possible anxiolytic or anxiogenic properties.

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Source
http://dx.doi.org/10.1016/s0149-7634(05)80136-8DOI Listing

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