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Efficacy, acceptability and tolerability of second-generation antipsychotics for behavioural and psychological symptoms of dementia: a systematic review and network meta-analysis.
BMJ Ment Health
July 2024
Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China
Article Synopsis
- Behavioural and psychological symptoms of dementia (BPSD) are common in dementia patients, and second-generation antipsychotics (SGAs) like brexpiprazole and aripiprazole are often used for treatment, but their effectiveness and acceptability were not well understood prior to this study.
- A network meta-analysis of 20 randomized controlled trials (involving 6,374 participants) assessed the efficacy, acceptability, and tolerability of five SGAs, revealing that brexpiprazole was the most effective, while aripiprazole had a better acceptability profile compared to placebo.
- Tolerability findings showed that olanzapine performed poorly with higher dropout rates due to adverse effects,
qEEG in the Diagnosis and Prognosis of a Case with Delusional Infestation.
Clin EEG Neurosci
March 2024
Istanbul Medeniyet University, Istanbul, Turkey.
Stroke can have neuropsychological consequences, such as poststroke psychosis. One aspect of poststroke psychosis is delusional infestation (DI), also known as delusional parasitosis. Patients with DI have fixed sensations that they get infested by lice.
View Article and Find Full Text PDFImplications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011-2022 Update.
Drugs Aging
January 2023
South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, London, UK.
Article Synopsis
- * The first approach to manage these symptoms should be non-medication strategies; however, if medications are necessary, second-generation antipsychotics are more commonly prescribed than first-generation.
- * Using antipsychotics in dementia patients can increase mortality and cause adverse effects; treatment decisions are complicated by various personal health factors, but risks can be reduced through careful monitoring and timely medication withdrawal.
Introduction: Dementia-related psychosis (DRP) is characterized by hallucinations and delusions, which may increase the debilitating effects of underlying dementia. This network meta-analysis (NMA) evaluated the comparative efficacy, safety, and acceptability of atypical antipsychotics (AAPs) commonly used off label to treat DRP.
Methods: We included 22 eligible studies from a systematic literature review of AAPs (quetiapine, risperidone, olanzapine, aripiprazole, and brexpiprazole) used off label to treat DRP.
Antipsychotic Medication-Induced Hyperthermia Leading to Cerebrovascular Accident: A Case Report.
Cureus
October 2021
Internal Medicine, Howard University, Washington, DC, USA.
Antipsychotic medications are used in the management of schizophrenia. Antipsychotic medications treat both positive and negative symptoms via the dopamine D2 receptor and serotonin 5-HT2A blockade pathway. Side effects include hyperprolactinemia, prolonged QTc, and neuroleptic malignant syndrome.
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