The illumination interpretation approach claims that lightness illusions can be explained as misapplications of lightness constancy mechanisms, processes which usually enable veridical extraction of surface reflectance from luminance distributions by discounting illumination. In particular, luminance gradients are thought to provide cues about the interactions of light and surfaces. Several examples of strong lightness illusions are discussed for which explanations based on illumination interpretation can be proposed. In criticisms of this approach, a variety of demonstrations of similarly structured control displays are presented, which involve equivalent lightness effects that cannot readily be accounted for by illumination interpretation mechanisms. Furthermore, a number of known and novel displays are presented that demonstrate effects of gradients on the qualitative appearance of uniform regions. Finally, some simple simulations of neural effects of luminance distributions are discussed.
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http://dx.doi.org/10.1163/156856806776923407 | DOI Listing |
Sens Diagn
December 2024
Department of Bioengineering, Rice University Houston TX 77030 USA
CRISPR-Cas-based lateral flow assays (LFAs) have emerged as a promising diagnostic tool for ultrasensitive detection of nucleic acids, offering improved speed, simplicity and cost-effectiveness compared to polymerase chain reaction (PCR)-based assays. However, visual interpretation of CRISPR-Cas-based LFA test results is prone to human error, potentially leading to false-positive or false-negative outcomes when analyzing test/control lines. To address this limitation, we have developed two neural network models: one based on a fully convolutional neural network and the other on a lightweight mobile-optimized neural network for automated interpretation of CRISPR-Cas-based LFA test results.
View Article and Find Full Text PDFThis essay is an attempt to determine what Robert Bernasconi's body of work in Critical Philosophy of Race can teach us about the way in which we, philosophers and professors of philosophy, ought to treat our institutional heritage. What should we make, for instance, of moral claims made by philosophers of the modern era who - tacitly or explicitly - manifested certain levels of endorsement toward the Atlantic Slave Trade? How should we comprehend the conceptual tools that we have inherited from them, knowing that those were formulated alongside justificatory claims for the enslavement of Africans - claims that we now deem undoubtably and universally immoral? I extract from Bernasconi's writings an implicit methodology that can be broken down into three main moves: (1) a historiographical work, akin to Michel Foucault's 'archaeological' method, aimed at uncovering the material conditions that allowed for the emergence of philosophical ideas of the past, (2) a dialectical work aimed at interpreting this collection of historical data through the critical lens of race, and (3) a pedagogical work aimed at transforming the practice of academic philosophy in light of the critique. I conclude that his methodological contribution culminates in an invitation to revisit and transform the past of the institution by treating the history of academic philosophy as philosophically and conceptually relevant rather than merely incidental.
View Article and Find Full Text PDFEcancermedicalscience
October 2024
Muhimbili University of Health and Allied Sciences (MUHAS), Dar es salaam 11103, Tanzania.
Acute leukemia (AL) is a diverse group of hematological malignancies characterised by the accumulation of immature blast cells in the bone marrow. Accurate classification into acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) is essential for treatment and prognosis. This study aimed to assess the performance of glass slide morphology (GSM) using a light microscope versus whole slide imaging (WSI) in diagnosing and classifying AL, using flow cytometry as the gold standard test.
View Article and Find Full Text PDFMicrob Biotechnol
January 2025
Fonterra Microbiome Research Centre, University College Cork, Cork, Ireland.
Advancing microbiome-gut-brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of the gut microbiome as a tractable therapeutic target for gastrointestinal, mental and brain health. Current research is still marked by many open questions that undermine widespread application to humans. For example, the lack of mechanistic understanding of probiotic effects means it remains unclear why even apparently closely related strains exhibit different effects in vivo.
View Article and Find Full Text PDFJ Alzheimers Dis
January 2025
Danish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background: Little is known about confounding factors influencing Alzheimer's disease (AD) blood biomarker concentrations.
Objective: The objective of this systematic review was to explore the available evidence for the influences of ethnicity and race on AD blood biomarker concentrations.
Methods: We conducted a comprehensive systematic search in PubMed and Web of Science databases spanning from inception until 15 June 2023.
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