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An ALK Immunohistochemical Pitfall: -Positive Histiocytosis Versus Angiomatoid Fibrous Histiocytoma.
Int J Surg Pathol
January 2025
Department of Pathology, VCU School of Medicine, Richmond, VA, USA.
The proliferation of recognized neoplasms related to related to rearrangements involving kinase genes, arising in diverse somatic tissue lineages, poses an increasing challenge in surgical pathology. For instance, ALK rearrangements have been observed in diverse neoplasms of epithelial, connective tissue, and hematolymphoid lineages, many of which are associated with overexpression of ALK by immunohistochemistry as a useful biomarker. An even higher order challenge and pitfall would be the scenario where a tumor an ALK rearrangement nonetheless overexpresses the protein, thereby simulating an ALK-defined neoplasm.
View Article and Find Full Text PDFRare Mandibular Surgical Ciliated Cysts: First Case Reported in a Brazilian.
Eur J Dent
December 2024
Department of Surgery, Stomatology, Pathology, and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
This reported case represents the first well-documented mandibular surgical ciliated cyst, following orthognathic surgery consisting of a combination of Le Fort I bimaxillary and sagittal osteotomy concomitantly with genioplasty, reported in a Brazilian patient. A case of 43-year-old female presenting a mandibular surgical ciliated cyst after 16 years of an orthognathic surgery, consisting of a combination of Le Fort I osteotomy and genioplasty, is reported. The cystic lesion was enucleated, and the histopathological analysis showed a cystic cavity lined by pseudostratified columnar respiratory-type epithelium presenting ciliated and mucous cells supported by fibrous connective tissue without inflammation.
View Article and Find Full Text PDFSerum pharmacochemistry combined with network pharmacology reveals the hepatotoxicity mechanism of Alangium chinense (Lour.) Harms.
J Ethnopharmacol
December 2024
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, 550025, China. Electronic address:
Article Synopsis
- A. chinense is historically used in traditional medicine by the Miao people for treating rheumatic pain, but it has potential toxic effects that need further investigation.
- This study utilizes serum metabolomics and network pharmacology to identify toxic components and mechanisms associated with A. chinense.
- Research findings showed that A. chinense elevated liver enzyme levels in rats, indicating possible hepatotoxicity, and detailed examinations analyzed the plant's effects and underlying toxic pathways.
"Pregnancy in a non-communicating rudimentary uterine horn managed with laparoscopy in the first trimester".
J Minim Invasive Gynecol
December 2024
Indigo womens centre, Chennai, India. Electronic address:
A 23-year-old woman, conceived by ovulation induction presented at 10 weeks amenorrhea with abdominal pain and a positive urinary Beta HCG. 2D ultrasound suggested a right-sided ectopic pregnancy. On 3D ultrasound imaging, an unicornuate uterus with a right rudimentary horn pregnancy of size 6 cm was diagnosed [Figure 1].
View Article and Find Full Text PDFAneurysm Is Restricted by CD34 Cell-Formed Fibrous Collars Through the PDGFRb-PI3K Axis.
Adv Sci (Weinh)
December 2024
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Aortic aneurysm is a life-threatening disease caused by progressive dilation of the aorta and weakened aortic walls. Its pathogenesis involves an imbalance between connective tissue repair and degradation. CD34 cells comprise a heterogeneous population that exhibits stem cell and progenitor cell properties.
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