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The implementation and side effect management of immune checkpoint inhibitors in gynecologic oncology: a JAGO/NOGGO survey.
BMC Cancer
January 2025
Young Academy of Gynecologic Oncology (JAGO), Nord-Ostdeutsche Gesellschaft für Gynäkologische Onkologie (NOGGO), Berlin, Germany.
Background: The integration of immune checkpoint inhibitors (ICIs) into routine gynecologic cancer treatment requires a thorough understanding of how to manage immune-related adverse events (irAEs) to ensure patient safety. However, reports on real-world clinical experience in the management of ICIs in gynecologic oncology are very limited. The aim of this survey was to provide a real-world overview of the experiences and the current state of irAE management of ICIs in Germany, Switzerland, and Austria.
View Article and Find Full Text PDFAssociations of fetal and infant growth with pubertal timing.
Arch Dis Child
January 2025
Pediatrics, Erasmus MC, Rotterdam, Netherlands
Objective: Impaired fetal and infant growth may cause alterations in developmental programming of the hypothalamic-pituitary-gonadal axis and subsequently pubertal development. We aimed to assess associations between fetal and infant growth and pubertal development.
Design: Population-based prospective birth cohort.
Stabilised hyaluronic acid gel marker versus surgical clips for tumour bed delineation in breast cancer radiotherapy using MRI-simulation.
Radiother Oncol
January 2025
Department of Radiation Oncology Olivia Newton-John Cancer Wellness & Research Centre Austin Health Victoria Australia; Department of Medical Imaging and Radiation Sciences, Monash University Clayton Victoria Australia; Genesis Care, Ringwood Private Hospital Victoria Australia.
Background And Purpose: Compare breast cancer tumour bed (TB) delineation using stabilised hyaluronic acid (sHA) gel and MRI-simulation versus surgical clips and CT-simulation within same patient cohort.
Materials And Methods: Prospective single arm study of patients undergoing breast conserving surgery. Patients had both clips (≥5) and sHA gel markers inserted to define the TB and underwent MRI and CT simulation scans.
Integration of MRI radiomics and clinical data for preoperative prediction of vascular invasion in breast cancer: A deep learning approach.
Magn Reson Imaging
January 2025
GE Healthcare, Guangzhou 510623, China.
Background: Accurate preoperative prediction of vascular invasion in breast cancer is crucial for surgical planning and patient management. MRI radiomics has shown promise in enhancing diagnostic precision. This study aims to evaluate the effectiveness of integrating MRI radiomic features with clinical data using a deep learning approach to predict vascular invasion in breast cancer patients.
View Article and Find Full Text PDFCarrier-free nanoparticles for cancer theranostics with dual-mode magnetic resonance imaging/fluorescence imaging and combination photothermal and chemodynamic therapy.
Int J Pharm
January 2025
The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157 Xiwu Road, Xi'an, Shaanxi 710004, China. Electronic address:
Both photothermal therapy (PTT) and chemodynamic therapy (CDT) are designed to focus their antitumor effect on only the tumor site, thereby minimizing unwanted severe damage to healthy tissue outside the tumor. However, each monotherapy is limited in achieving complete tumor eradication, resulting in tumor recurrence. The combination of multiple therapies may help to overcome the limitations of single therapy, improve the chances of complete tumor eradication, and reduce the risk of recurrence.
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