DNA transactions of a wide variety generally require three major types of enzymatic activities: nucleases, polymerases, and ligases. V(D)J recombination is no exception. In this issue, Bertocci et al. (2006) have provided new insight by generating mice deficient in one or more of the polymerases.
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| http://dx.doi.org/10.1016/j.immuni.2006.07.007 | DOI Listing |
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