AI Article Synopsis
- * The exact reason for the long delay from injury to diagnosis is still unclear, though some cases link older age and hepatitis virus infection as contributing factors.
- * The authors suggest that the combination of aging or diseases causing low oxygen levels (hypoxia) could trigger the liver to produce blood cells after spleen injury, as blood precursor cells may travel from the spleen to the liver through the portal vein.
Article Abstract
Intrahepatic splenosis is a rare disorder of ectopic erythropoiesis in the liver. Although traumatic splenic rupture is the common factor in public cases, the mechanism of long latency is still unknown. The correlation between aging and hepatitis virus infection with the diagnosed occurrence was reported in a limited number of cases; nevertheless, it suggested that ectopic erythropoiesis in the liver could be induced by the hepatic disorder. Based on the susceptibility of the splenic erythropoiesis response to hypoxia and the inevitability of hypoxia caused by aging or pathological changes, we hypothesized that the two events caused the occurrence of the intrahepatic splenosis, the migration of the erythrocytic progenitor cells via the portal vein following traumatic splenic rupture, and the local induction of erythropoiesis by hypoxia.
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| http://dx.doi.org/10.1016/j.mehy.2006.04.064 | DOI Listing |
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