An extrapulmonary neuroendocrine tumor arising in the prostate gland has been described in several case series; however, pure and primary prostatic neuroendocrine tumors are very rare, their biologic behavior is not yet well known, and there are only a few reports in the literature describing the clinical features and management of this neoplasm. This article presents the clinicopathologic findings of 2 patients presenting with this disease. The published reports of primary pure neuroendocrine prostate tumors are discussed.
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http://dx.doi.org/10.3816/CGC.2006.n.022 | DOI Listing |
Int J Pharm
January 2025
Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India. Electronic address:
Depression is a common mental condition causing depressed mood and loss of pleasure. The primary treatment approach for the management of depression consists of the use of selegiline (MAO-B) inhibitor compound. The present work aimed to develop and optimize selegiline-loaded nanostructured lipid carriers for transdermal application, utilizing a 2 full factorial design approach.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science, School of Environmental Studies, China University of Geosciences, Wuhan 430074, PR China. Electronic address:
Microorganisms that utilize organic matter to reduce Fe oxides/hydroxides constitute the primary geochemical processes controlling the formation of high-arsenic (As) groundwater. Biogenic secondary iron minerals play a significant role in As migration. However, the influence of quinone electron shuttles and competitive anionic phosphate on this process has not been thoroughly studied.
View Article and Find Full Text PDFWater Res
January 2025
Department of Civil and Environmental Engineering, University of Florence, Via di S. Marta, 3, 50139, Firenze, Italy.
The performance of Upflow Anaerobic Sludge Blanket (UASB) bioreactors treating sulfate (SO) -rich effluents depends on multiple factors, including microbial interactions and operational conditions. The high complexity of these systems necessitates the use of mathematical modelling tools to better understand the process and predict the long-term impacts of various operational variables. In this work, a mathematical model describing the long-term operation of a sulfate-fed 2.
View Article and Find Full Text PDFNeuro Oncol
January 2025
Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg.
Background: Peripheral nerve sheath tumors (PNSTs) encompass entities with different cellular differentiation and degrees of malignancy. Spatial heterogeneity complicates diagnosis and grading of PNSTs in some cases. In malignant PNST (MPNST) for example, single cell sequencing data has shown dissimilar differentiation states of tumor cells.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.
Essential oils (EOs) exhibit a broad spectrum of biological activities; however, their clinical application is hindered by challenges, such as variability in chemical composition and chemical/physical instability. A critical limitation is the lack of chemical consistency across EO samples, which impedes standardization. Despite this, evidence suggests that EOs with differing chemical profiles often display similar (micro)biological activities, raising the possibility of standardizing EOs based on their biological effects rather than their chemical composition.
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