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http://dx.doi.org/10.1126/science.1130482 | DOI Listing |
Cancer Med
February 2025
Department of Radiation Oncology (MAASTRO) GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands.
Background: Lung cancer (LC) is the top cause of cancer deaths globally, prompting many countries to adopt LC screening programs. While screening typically relies on age and smoking intensity, more efficient risk models exist. We devised a Bayesian network (BN) for LC detection, testing its resilience with varying degrees of missing data and comparing it to a prior machine learning (ML) model.
View Article and Find Full Text PDFCurr Opin Psychiatry
March 2025
Neuropsychiatry Unit, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México.
Purpose Of Review: Autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), and autoimmune encephalitis can directly and indirectly affect brain function, leading to cognitive dysfunction or well characterized neurocognitive syndromes. However, these are often poorly characterized in the literature. Here, we review evidence on clinical manifestations, risk factors, their assessment and outcomes, and evidence for underlying mechanisms and associated biomarkers, if available.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Solid organ transplant recipients (SOTRs) suffer more frequent and more severe infections due to their compromised immune responses resulting from immunosuppressive treatments designed to prevent organ rejection. Pharmacological immunosuppression can adversely affect immune responses to vaccination. A cohort of kidney transplant recipients (KTRs) received their third dose of ancestral, monovalent COVID-19 vaccine in the context of a clinical trial and antibody responses to the vaccine strain, as well as two Omicron variants BA.
View Article and Find Full Text PDFVaccine X
October 2024
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
We conducted a test negative study from November 2023 to June 2024, enrolling 4,367 children hospitalized with acute respiratory illness in Hong Kong. Among the children who tested negative for influenza virus and SARS-CoV-2, 56.8 % had received influenza vaccination.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
Background: Toxoplasmosis in pregnancy is associated with serious and irreversible maternal and fetal detrimental consequences. Also, different seroprevalence of Toxoplasma gondii in pregnancy is reported in many countries. The present systematic review and meta-analysis study aimed to determine the global seroprevalence of Toxoplasma gondii in pregnant women.
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