Purpose: To compare tilt and some higher-order aberrations (HOAs) in patients who had cataract surgery and implantation of 2 types of acrylic intraocular lens (IOL), the hydrophobic MA60AC (Alcon) or the hydrophilic XLSTABI (Ioltech).
Setting: Fondation Ophtalmologique Adolphe de Rothschild, Department of Pr Hoang-Xuan, Paris, France.
Methods: Sixty eyes were included in this study. Eyes in group 1 (n = 30) received the acrylic hydrophobic MA60AC IOL, and eyes in group 2 (n = 30) received the acrylic hydrophilic XLSTABI IOL. Optical aberrations were measured with Nidek OPD-Scan at least 1 month after cataract surgery for a 6.0 mm pupil diameter using a 6th-order Zernike polynomials decomposition.
Results: In group 1, the mean root-mean-square (RMS) coefficient for the total higher aberration was 0.86 microm +/- 0.38 (SD). The mean RMS of the tilt, coma, trefoil, tetrafoil, spherical aberration, and secondary astigmatism was 0.81 +/- 0.45 microm, 0.38 +/- 0.30 microm, 0.55 +/- 0.18 microm, 0.13 +/- 0.23 microm, 0.30 +/- 0.13 microm, and 0.17 +/- 0.21 microm, respectively. In group 2, the mean RMS coefficient for the total higher aberration was 0.72 +/- 0.31 microm. The mean RMS of the tilt, coma, trefoil, tetrafoil, spherical aberration, and secondary astigmatism was 0.55 +/- 0.30 microm, 0.24 +/- 0.19 microm, 0.50 +/- 0.23 microm, 0.07 +/- 0.22 microm, 0.32 +/- 0.13 microm, and 0.14 +/- 0.14 microm, respectively. There was a statistical difference in aberrations between the 2 groups for the tilt and the coma aberrations (P<.05). There were more aberrations in the MA60AC IOL group.
Conclusions: The design of the IOL influenced ocular aberrations after cataract surgery. There were more tilt and coma aberrations in the MA60AC IOL group.
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http://dx.doi.org/10.1016/j.jcrs.2006.01.099 | DOI Listing |
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College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:
Neuronal nitric oxide synthase (nNOS) is regulated by phosphorylation in vivo, yet the underlying biochemical mechanisms remain unclear, primarily due to difficulty in obtaining milligram quantities of phosphorylated nNOS protein; detailed spectroscopic and rapid kinetics investigations require purified protein samples at a concentration in the range of hundreds microM. Moreover, the functional diversity of the nNOS isoform is linked to its splice variants. Also of note is that determination of protein phosphorylation stoichiometry remains as a challenge.
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Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia. Electronic address:
Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occur in more than 2.7 million women/year and account for 22% of cancer-related deaths/year.
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