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Investigation of ADAMTS-13 levels in patients with COVID-19 infection.
J Infect Dev Ctries
September 2024
Department of Pediatric Hematology and Oncology, Faculty of Medicine, Usak University, Usak, Turkiye.
Article Synopsis
- COVID-19 patients have a higher risk of blood clotting issues, possibly linked to ADAMTS-13 levels, a protein that helps regulate blood clotting.
- A study on 180 patients categorized them into mild and severe COVID-19 groups, comparing their ADAMTS-13 levels with a control group, using various clinical tests.
- Results showed no significant differences in ADAMTS-13 levels between the groups, suggesting that it may not be a reliable biomarker for assessing patient risk upon admission.
Hematological features and alternate diagnoses in critically ill thrombotic antiphospholipid syndrome patients.
Clin Rheumatol
September 2024
Syndrome Des Anticorps Anti-Phospholipides Et Autres Maladies Auto-Immunes Systémiques Rares, Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital La Pitié-Salpêtrière, Institut E3M, Service de Médecine Interne 2, Centre de Référence National Lupus Systémique, Paris, France.
Article Synopsis
- Severe thrombotic antiphospholipid syndrome (APS) significantly affects critical organs and has not been thoroughly studied in ICU patients, particularly regarding hematological issues.
- A retrospective study in France tracked 134 APS patients in ICUs, revealing high rates of anemia (95%) and thrombocytopenia (93%), with low platelet counts linked to increased mortality.
- The findings highlight the importance of understanding the causes of thrombocytopenia in APS patients, as conditions like thrombotic microangiopathy (TMA), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC) are prevalent in this population.
Weibel-Palade bodies: function and role in thrombotic thrombocytopenic purpura and in diarrhea phase of STEC-hemolytic uremic syndrome.
Pediatr Nephrol
January 2025
Department of Physiology, Radboud University Centre, Nijmegen, the Netherlands.
Vascular endothelial cells are equipped with numerous specialized granules called Weibel-Palade bodies (WPBs). They contain a cocktail of proteins that can be rapidly secreted (3-5 min) into the vascular lumen after an appropriate stimulus such as thrombin. These proteins are ready without synthesis.
View Article and Find Full Text PDFRisk factors of death or chronic renal replacement therapy requirements in patients with thrombotic microangiopathies without ADAMTS-13 deficiency.
Eur J Haematol
October 2024
Fundació Institut d'Investigació Sanitària Illes Balears (IdISBa), Hospital Universitario Son Espases, Palma de Mallorca, Balearic Islands, Spain.
Thrombotic microangiopathy (TMA), characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multisystem organ dysfunction, is a life-threatening disease. Patients with TMA who do not exhibit a severe ADAMTS-13 deficiency (defined as a disintegrin-like and metalloprotease with thrombospondin type 1 motif no. 13 activity ≥10%: TMA-13n) continue to experience elevated mortality rates.
View Article and Find Full Text PDFVascular endothelial-cadherin is involved in endothelial cell detachment during thrombotic thrombocytopenic purpura.
J Thromb Haemost
October 2024
French Reference Center for Thrombotic Microangiopathies, Paris, France; Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Universitaire (CHU) Conception, Service de médecine interne et d'immunologie clinique, Marseille, France.
Article Synopsis
- Immune thrombotic thrombocytopenic purpura (i-TTP) is a serious condition characterized by a deficiency in ADAMTS-13 and is thought to start with the activation of endothelial cells, leading to vascular damage.
- The study aimed to explore how endothelial cells detach during thrombotic thrombocytopenic purpura by examining circulating endothelial cells (CECs) in patients and their relationship to disease severity and calcium signaling.
- Results showed that plasma from i-TTP patients led to greater detachment and altered behavior of endothelial cells compared to control plasma, suggesting that increased vascular permeability may be a key factor in the pathogenesis of the disease.
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