AI Article Synopsis
- The study investigates the effects of di-(2-ethylhexyl) phthalate (DEHP) on male ICR mice, particularly focusing on the testes, liver, kidneys, and pancreas after 10 days of exposure to a 2% DEHP diet.
- Results demonstrated severe damage to spermatogenesis and liver function, with high levels of nitrogen oxides and lipid peroxidation detected in the testes, indicating stress from free radicals.
- The findings suggest that the detrimental effects on sperm production are due to the sensitivity of testicular tissues to mono-(2-ethylhexyl) phthalate (MEHP), not its accumulation in the testes.
Article Abstract
Aim: To determine the biochemical effect of di-(2-ethylhexyl) phthalate (DEHP) on testes, liver, kidneys and pancreas on day 10 in the process of degeneration of the seminiferous epithelium.
Methods: Diets containing 2% DEHP were given to male Crlj:CD1(ICR) mice for 10 days. The dose of DEHP was 0.90 +/- 0.52 mg/mouse/day. Their testes, livers, kidneys and pancreata were examined for detection of mono-(2-ethylhexyl) phthalate (MEHP), nitrogen oxides (NOx) produced by peroxidation of nitric oxide (NO) with free radicals, and lipid peroxidation induced by the chain reaction of free radicals.
Results: Histological observation and serum analysis showed the presence of severe spermatogenic disturbance, Leydig cell dysfunction, liver dysfunction and dehydration. Unexpectedly, the concentration of MEHP in the testes was extremely low compared with that in the liver. However, the concentration of the NOx in the testes was as high as the hepatic concentration. Furthermore, free radical-induced lipid peroxidation was histochemically detected in the testes but not in the liver.
Conclusion: The results indicate that DEHP-induced aspermatogenesis is caused by the high sensitivity of the testicular tissues to MEHP rather than the specific accumulation or uptake of circulating MEHP into the testes.
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| http://dx.doi.org/10.1111/j.1745-7262.2007.00220.x | DOI Listing |
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