Aim: To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients.

Methods: We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.).

Results: Adiponectin levels were 16.9 +/- 7.3 mg/mL at baseline and 13.5 +/- 7.4 mg/mL at month 6 of T treatment (P < 0.05). Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected.

Conclusion: T can significantly reduce adiponectin serum levels in transsexual female patients.

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Source
http://dx.doi.org/10.1111/j.1745-7262.2006.00204.xDOI Listing

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