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Computed tomographic findings in dogs with ovarian tumors: A tortuous ovarian artery consistently identifies ovarian origin in complex abdominal masses.
Vet Radiol Ultrasound
January 2025
Department of Veterinary Medicine, Università degli Studi di Milano, Lodi, Italy.
The aim of this retrospective multicentric case series is to describe the CT findings of ovarian neoplasia in dogs. Twenty dogs with pre- and postcontrast CT exams and cytological/histological diagnosis of ovarian neoplasia were included. Five dogs presented with bilateral tumors, for a total of 25 neoplasms: 15 carcinomas (4 bilateral), 4 granulosa cell tumors, 2 poorly differentiated malignant neoplasia (bilateral), 2 luteomas, 1 teratoma, 1 dysgerminoma.
View Article and Find Full Text PDFChallenging clinical management of a patient with Gaucher disease type IIIC homozygous for the D409H mutation, aortic valve calcification and porcelain aorta.
Turk J Pediatr
November 2024
Department of Cardiology, Hacettepe University Hospital, Ankara, Türkiye.
Background: Gaucher disease is a rare lysosomal storage disorder caused by glucocerebrosidase enzyme deficiency resulting in the cumulative deposition of glucocerebroside in macrophages, predominantly effecting bone marrow, liver and spleen. Gaucher disease type IIIC is a rare subtype that is characterized by cardiovascular involvement, eye-movement disorders, and late-onset neurological symptoms.
Case Presentation: We present a 14-year-old adolescent boy diagnosed with Gaucher disease type IIIC at age four with a homozygous D409H mutation who developed severe aortic valve stenosis, extensive aortic calcification and a porcelain aorta despite enzyme replacement treatment since the diagnosis.
Background & Aims: Responses to immunotherapies in hepatocellular carcinoma (HCC) are suboptimal with no biomarkers to guide patient selection. "Humanized" mice represent promising models to address this deficiency but are limited by variable chimerism and underdeveloped myeloid compartments. We hypothesized that expression of human GM-CSF and IL-3 increases tumor immune cell infiltration, especially myeloid-derived cells, in humanized HCC patient-derived xenografts (PDXs).
View Article and Find Full Text PDFStent-graft implantation for late postpancreatectomy hemorrhage after pancreatoduodenectomy.
Chin J Traumatol
October 2024
Vascular Surgery, Department of General Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. Electronic address:
Purpose: Postpancreatectomy hemorrhage (PPH) is a life-threatening complication after pancreatoduodenectomy. Stent-graft implantation is an emerging treatment option for PPH. This study reports the outcome of PPH treated with stent-graft implantation.
View Article and Find Full Text PDFKCl enhances the cryoablation-induced antitumor immune response: A hepatocellular carcinoma murine model research.
Cryobiology
December 2024
Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, China; Shanghai Technical Service Platform for Cryopreservation of Biological Resources, Shanghai, China; Shanghai Collaborative Innovation Center for Tumor Treatment with Energy, Shanghai, China. Electronic address:
Cryoablation is a valuable treatment for liver cancer. To investigate the effect of KCl solution on the immunological response post cryoablation, we created a tumor-bearing mice model by subcutaneously implanting Hepal-6 cells in adult Balb/c mice. Subsequently, the mice were randomly assigned to three groups: group A (sham cryoablation), group B (cryoablation), and group C (cryoablation plus KCl solution).
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