Transcriptional profile of Haemophilus influenzae: effects of iron and heme.

J Bacteriol

Department of Pediatrics, CHO 2308, 940 NE 13th St., Oklahoma City, OK 73104, USA.

Published: August 2006

Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing approximately 10% of the genome, with > or =1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540045PMC
http://dx.doi.org/10.1128/JB.00417-06DOI Listing

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