AI Article Synopsis
- "Uropathogenic Escherichia coli" (UPEC) refers to specific E. coli strains that lead to urinary tract infections (UTIs), which are also linked to infections in other parts of the body, leading to the broader term "extraintestinal pathogenic E. coli" (ExPEC).
- These ExPEC strains mainly belong to the B2 phylogenetic group and contain virulence genes organized in pathogenicity islands (PAIs), contributing to their ability to cause disease.
- Factors such as the vaginal ecosystem, intestinal E. coli populations, sexual activity, and the urinary tract's physical conditions, along with E. coli's ability to form biofilms, are critical in understanding how UTIs occur and why they can recur,
Article Abstract
"Uropathogenic Escherichia coli" has been the term used to describe E. coli strains able to cause urinary tract infections. Their molecular characterization has demonstrated that these strains are the same as those causing infections in non-urinary extraintestinal locations, and it has been proposed thus the more inclusive term "extraintestinal pathogenic E. coli" or "ExPEC" to use. ExPEC derive mainly from the phylogenetic B2 group and harbor genes that codify virulence, such as fimH, papA, papG allele II, kspM II, hlyA, cnf1, fyuA, iutA, and traT, which are grouped in pathogenicity islands (PAIs). The vaginal ecosystem and especially Lactobacillus, as well as intestinal populations of E. coli, coitus and the physiological and anatomical conditions of the urinary tract also play a major role in the pathogenesis of urinary tract infections. The persistence of E. coli in bladder "biofilms" or "pods" or in the fecal reservoir could explain recurrent infections in young women.
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| http://dx.doi.org/10.1157/13091444 | DOI Listing |
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