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Rapid and Deep Prostate-Specific Antigen Decline is a Prognostic Marker in Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Multi-Intuitional Analysis.
Prostate
December 2024
Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Background: Prostate-specific antigen (PSA) kinetics has been investigated as a prognostic marker in post hoc analyses of clinical trials. This study validated the prognostic value of rapid and deep PSA decline in metastatic hormone-sensitive prostate cancer (mHSPC) using real-world data.
Methods: In total, 1296 patients with mHSPC were retrospectively reviewed.
The application of new type ureteroscope and traditional linear ureteroscope in ureteric stone patients.
BMC Urol
December 2024
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100032, PR China.
Objective: A ureteric stone is a type of urinary tract stone that is found within the ureter. While most cases can be managed with conservative treatment or minimally invasive surgery, these methods often cause significant pain for the patient. Interestingly, a new type of ureteroscope has shown considerable promise in treating patients with ureteric stones, and this study aims to explore its clinical application.
View Article and Find Full Text PDFMobile app communication to prevent ER visits post-circumcision: a prospective observational study.
Int Urol Nephrol
December 2024
Cumhuriyet University Hospital, Sivas, Turkey.
Purpose: To assess the impact of a mobile phone application facilitating real-time visual and verbal communication on reducing emergency-room admissions following circumcision.
Methods: This prospective observational study included circumcision surgeries performed by one surgeon at our clinic between April and June 2024, after obtaining parental consent. Parents were divided into two groups: one received a mobile app phone number, while the other did not.
Artificial Intelligence (AI) and Men's Health Clinic Efficiency and Clinic Billing.
Curr Urol Rep
December 2024
Department of Urology, Lahey Hospital and Medical Center, MA, Burlington, USA.
Purpose Of Review: Artificial Intelligence (AI) has produced a significant impact across various industries, including healthcare. In the outpatient clinic setting, AI offers promising improvements in efficiency through Chatbots, streamlined medical documentation, and personalized patient education materials. On the billing side, AI technologies hold potential for optimizing the selection of appropriate billing codes, automating prior authorizations, and enhancing healthcare fraud detection.
View Article and Find Full Text PDFInhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer.
Neoplasia
December 2024
General Surgery Center Department of Thyroid Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China; Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, PR China. Electronic address:
Immunotherapy with checkpoint inhibitors produced significant clinical responses in a subset of cancer patients who were resistant to prior therapies. However, Castration-resistant prostate cancer (CRPC) is seriously lack of T cell infiltration, which greatly limits the clinical application of immunotherapy, but the mechanism is unclear. In the present study, in silico analyses and experimental data show that HnRNP L was significantly negatively correlated with CD4+ and CD8+ T cells infiltration in patients; besides, we found deficiency of HnRNP L recruites CD4+ and CD8+ T cells infiltration and impairs tumorigenesis.
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