AI Article Synopsis
- The rggC locus in Streptococcus thermophilus contains a frameshift mutation resulting in two open reading frames that encode proteins similar to Rgg transcriptional regulators.
- Researchers created mutants with partial deletions of rggC (1) and rggC (2) to study their responses to oxidative stress caused by menadione, revealing different behaviors compared to the wild-type strain.
- Analysis of this locus across 21 S. thermophilus strains showed variability in a polythymine tract and strain-dependent adenine residues, suggesting that the rggC locus is phase variable.
Article Abstract
In Streptococcus thermophilus, the locus rggC contains a frameshift mutation and thus consists of two open reading frames (ORFs), rggC (1) and rggC (2), which encode proteins exhibiting similarity with the Rgg transcriptional regulator family. In this work, mutants showing a partial deletion of rggC (1) and rggC (2 )were constructed and their response to menadione, a superoxide-generating compound, was analysed. These mutants exhibited different behaviour to this oxidative stress compared with the wild-type strain. Analysis of this locus among 21 strains of S. thermophilus showed a polythymine tract length variability and a strain-dependant adenine residue could be found upstream of this repeat. This interstrain polymorphism supports evidence for the hypothesis that the rggC locus is phase variable.
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| http://dx.doi.org/10.1007/s00203-006-0130-8 | DOI Listing |
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The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus.
Arch Microbiol
September 2006
Laboratoire de Génétique et Microbiologie, UMR INRA 1128, IFR 110, Faculté des Sciences et Techniques de l'Université Henri Poincaré, Campus de Grignard, BP239, 54506 Vanoeuvre-lès-Nancy, France.
Article Synopsis
- The rggC locus in Streptococcus thermophilus contains a frameshift mutation resulting in two open reading frames that encode proteins similar to Rgg transcriptional regulators.
- Researchers created mutants with partial deletions of rggC (1) and rggC (2) to study their responses to oxidative stress caused by menadione, revealing different behaviors compared to the wild-type strain.
- Analysis of this locus across 21 S. thermophilus strains showed variability in a polythymine tract and strain-dependent adenine residues, suggesting that the rggC locus is phase variable.
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