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Once-Weekly Insulin: A Breakthrough in Diabetes Management or an Unresolved Challenge?
Br J Hosp Med (Lond)
January 2025
Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
The advent of once-weekly insulin icodec is a promising development in the care of individuals with diabetes. These once-weekly formulations aimed to improve patient adherence and quality of life for patients who find daily injection administration challenging. Insulin icodec has demonstrated comparable glycemic control to conventionally used daily basal insulins, such as insulin glargine and degludec, in the ONWARDS clinical trials.
View Article and Find Full Text PDFI/D Genotype and Risk of Non-Contact Injury in Moroccan Elite Athletes: A Pilot Study.
Medicina (Kaunas)
January 2025
M2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, University Rennes, 35000 Rennes, France.
The insertion/deletion (I/D) polymorphism in , the gene encoding the angiotensin-converting enzyme (ACE), has been suggested as a genetic variation that can influence exercise performance and risk of injury in elite athletes. The I allele has been associated with enhanced endurance performance and with reduced inflammation, while the D allele has been associated with improved performance in strength and power activities. However, the role of this genetic variant in the incidence of non-contact injury is underexplored.
View Article and Find Full Text PDFAssessing spatially explicit long-term landscape dynamics based on automated production of land category layers from Danish late nineteenth-century topographic maps in comparison with contemporary maps.
Environ Monit Assess
January 2025
Royal Danish Library, Special Collections, Søren Kierkegaards Plads. 1, 1221, Copenhagen K, Denmark.
Historical topographical maps contain valuable, spatially and thematically detailed information about past landscapes. Yet, for analyses of landscape dynamics through geographical information systems, it is necessary to "unlock" this information via map processing. For two study areas in northern and central Jutland, Denmark, we apply object-based image analysis, vector GIS, colour image segmentation, and machine learning processes to produce machine-readable layers for the land use and land cover categories forest, wetland, heath, dune sand, and water bodies from topographic maps from the late nineteenth century.
View Article and Find Full Text PDFIdentifying Patient Subgroups in the Heterogeneous Chronic Pain Population Using Cluster Analysis.
J Pain
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Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Chronic pain is an ill-defined disease with complex biopsychosocial aspects, posing treatment challenges. We hypothesized that treatment failure results, at least partly, from limited understanding of diverse patient subgroups. We aimed to identify subgroups using psychological variables, allowing for more tailored interventions.
View Article and Find Full Text PDFPathophysiology of Penetrating Captive Bolt Stunning in Horned and Polled Sheep and Factors Determining Incomplete Concussion.
Vet Sci
January 2025
Independent Researchers, UK.
Penetrating captive bolt (PCB) is widely used for stunning and on-farm dispatch of livestock, yet its efficacy can vary, with the potential for animal welfare compromise. This study investigated the pathophysiology of PCB-induced trauma in horned and polled sheep (), focusing on factors contributing to incomplete concussion. Thirty-seven ( = 18 horned Scottish blackface and = 19 polled North Country mule) mature ewes (aged 4-10 years) were shot with PCB with varying cartridge power and PCB modifications, followed by clinical assessment and post-mortem analysis using magnetic resonance imagining (MRI) and gross pathology.
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