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Frequency of "PCOS" and "Being at Risk for PCOS" in Obese Adolescent Girls in Light of Current Definitions.
J Clin Res Pediatr Endocrinol
January 2025
University of Health Sciences, Ümraniye Training and Research Hospital, Department of Pediatric Endocrinology, Istanbul.
Introduction: Obesity is associated with an increased risk of PCOS. It can be difficult to differentiate between PCOS and physiological oligomenorrhoea/anovulation in adolescent girls. To date, studies of the prevalence of PCOS in adolescents have predominantly used diagnostic criteria validated primarily in adult women.
View Article and Find Full Text PDFTrans-ancestry genome wide association study of childhood body mass index identifies novel loci and age-specific effects.
HGG Adv
January 2025
Department of Epidemiology, UNC Chapel Hill, Chapel Hill, NC 27514. Electronic address:
Over the past 30 years, obesity prevalence has markedly increased globally, including among children. Although genome-wide association studies (GWAS) have identified over 1,000 genetic loci associated with obesity-related traits in adults, the genetic architecture of childhood obesity is less well-characterized. Moreover, most childhood obesity GWAS have been restricted to severely obese children, in relatively small sample sizes, and in primarily European ancestry populations.
View Article and Find Full Text PDFPediatric obesity and the risk of multiple sclerosis: a nationwide prospective cohort study.
Int J Obes (Lond)
January 2025
Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, S-141 57, Huddinge, Sweden.
Background: Emerging evidence implies a link between high pediatric body mass index (BMI) and an increased risk of multiple sclerosis (MS). However, previous research suggests this association is only present for adolescent obesity and not childhood obesity. The present study aimed to assess the association between pediatric obesity and risk of developing MS, and to investigate if degree of obesity and age at obesity treatment initiation affects the risk.
View Article and Find Full Text PDFThe importance of thiamine availability in the thermogenic competency of human adipocytes.
Mol Cell Endocrinol
January 2025
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032, Debrecen, Hungary. Electronic address:
Brown and beige adipocytes express uncoupling protein-1 (UCP1), which is located in the inner mitochondrial membrane and facilitates the dissipation of excess energy as heat. The activation of thermogenic adipocytes is a potential therapeutic target for treating type 2 diabetes mellitus, obesity, and related co-morbidities. Therefore, identifying novel approaches to stimulate the function of these adipocytes is crucial for advancing therapeutic strategies.
View Article and Find Full Text PDFThe Association Between Physical Activity and Markers of Obesity in Children Living With Obesity.
Pediatr Exerc Sci
January 2025
INTEGRA-Integrative Physiology, Health, and Performance Research Group, Federal University of Rio Grande do Norte, Natal, RN,Brazil.
Purpose: The purpose of this study is to describe the association between the volume and intensity of accelerometer-assessed physical activity (PA) and markers of obesity.
Method: Forty-seven children (20 girls) took part in this investigation. Children wore accelerometers on their nondominant wrists for 7 days.
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