Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
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A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Bioorg Med Chem Lett
September 2006
Department of Medicinal Chemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, S-431 83 Mölndal, Sweden.
Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.
View Article and Find Full Text PDFStructure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Bioorg Med Chem Lett
September 2006
Department of Medicinal Chemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, S-431 83 Mölndal, Sweden.
Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
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