AI Article Synopsis
- The study investigated how alacepril, CV-11974, and spironolactone impact the levels of MCP-1 and TNF-alpha in human immune cells triggered by angiotensin II.
- All three medications were found to significantly decrease the production of these inflammatory markers when stimulated by angiotensin II, with spironolactone showing the most pronounced effect.
- These results suggest that spironolactone could help improve the outcomes for patients with cardiovascular diseases by lessening inflammation caused by angiotensin II, but further research is needed to understand the underlying mechanisms.
Article Abstract
We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Specifically, 10 muM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.
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| http://dx.doi.org/10.1254/jphs.sc0060049 | DOI Listing |
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Article Synopsis
- The study investigated how alacepril, CV-11974, and spironolactone impact the levels of MCP-1 and TNF-alpha in human immune cells triggered by angiotensin II.
- All three medications were found to significantly decrease the production of these inflammatory markers when stimulated by angiotensin II, with spironolactone showing the most pronounced effect.
- These results suggest that spironolactone could help improve the outcomes for patients with cardiovascular diseases by lessening inflammation caused by angiotensin II, but further research is needed to understand the underlying mechanisms.
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