AI Article Synopsis
- F1C fimbriae help uropathogenic Escherichia coli stick to specific surfaces thanks to special minor components.
- The foc gene cluster that encodes these fimbriae has been cloned, and the study provides the nucleotide sequence for the F1C minor fimbrial subunits.
- The amino acid sequences of these subunits show high similarity to Sfa proteins but less similarity to the minor subunits of other fimbriae types.
Article Abstract
F1C fimbriae allow uropathogenic Escherichia coli to adhere to specific epithelial surfaces. This adhesive property is probably due to the presence of minor fimbrial components in F1C fimbriae. The foc gene cluster encoding F1C fimbriae has been cloned, as described previously. Here we present the nucleotide sequence (2081 bp) coding for the F1C minor fimbrial subunits. The structural genes code for polypeptides of 175 (FocF), 166 (FocG), and 300 (FocH) amino acids. The deduced amino acids of the F1C minor subunits were compared with the reported sequences of the minor subunits of other types of fimbriae. The data show that the Foc minor subunits are highly homologous to the corresponding Sfa proteins, whereas homology to the minor subunits of type 1 and P fimbriae is much lower.
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| http://dx.doi.org/10.1016/0923-2508(91)90078-o | DOI Listing |
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