Polymerase chain reaction-based replicon typing represents a novel method to describe the dissemination and follow the evolution of resistance plasmids. We used this approach to study 26 epidemiologically unrelated Enterobacteriaceae and demonstrate the dominance of incompatibility (Inc) A/C or Inc N-related plasmids carrying some emerging resistance determinants to extended-spectrum cephalosporins and carbapenems.
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http://dx.doi.org/10.3201/eid1207.051555 | DOI Listing |
Antibiotics (Basel)
December 2024
Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg 197022, Russia.
Carbapenem-resistant (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant () and () isolated from Russian hospitals. : We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 and 5 ) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022.
View Article and Find Full Text PDFBMC Microbiol
January 2025
Central Research Institute of Epidemiology, Novogireevskaya Str., 3a, Moscow, 111123, Russia.
Background: The infections of bacterial origin represent a significant problem to the public healthcare worldwide both in clinical and community settings. Recent decade was marked by limiting treatment options for bacterial infections due to growing antimicrobial resistance (AMR) acquired and transferred by various bacterial species, especially the ones causing healthcare-associated infections, which has become a dangerous issue noticed by the World Health Organization. Numerous reports shown that the spread of AMR is often driven by several species-specific lineages usually called the 'global clones of high risk'.
View Article and Find Full Text PDFJ Food Prot
December 2024
Department of Population Health & Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA. Electronic address:
Salmonella species are an important cause of systemic and gastrointestinal disease in animals and humans worldwide; they are also increasingly resistant to multiple classes of antimicrobials which may aid in their treatment and control. Salmonella can also be shed asymptomatically. The aim of this study was to survey the U.
View Article and Find Full Text PDFFront Vet Sci
November 2024
Department of Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Introduction: Carbapenem-resistant Enterobacterales (CRE), particularly carbapenemase-producing , pose a significant global health challenge due to their resistance to last-resort antibiotics. This study investigates the genetic characteristics and clonal relationships of CRE isolated from canine and human clinical samples in Bangkok to understand potential interspecies transmission.
Methods: Fifty-two CRE isolates were collected from 477 clinical samples from dogs and humans at Chulalongkorn University between 2017-2021.
J Glob Antimicrob Resist
December 2024
Antimicrobial Resistance and Microbial Ecology Group, School of Medicine, University of Galway, Galway, Ireland; Centre for One Health, Ryan Institute, University of Galway, Galway, Ireland. Electronic address:
Objectives: While Escherichia coli phylogroup-A is typically associated with commensal strains, some isolates can harbour virulence and exhibit multidrug-resistant (MDR) phenotypes. We report the draft genome of a rare instance of carbapenem, fosfomycin and colistin resistant E. coli phylogroup-A, isolated as part of routine screening of a human patient in a clinical setting in Ireland.
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