A case of effective paclitaxel therapy for gastric cancer with brain metastasis is reported. The patient was a 76-year-old male, who underwent total gastrectomy for advanced gastric carcinoma with direct invasion of the pancreas. One year and six months later, he was resected for a right temporal-occipital brain metastatic tumor, and local cerebral irradiation at 30 Gy was performed. Four months later, new multiple brain metastases were detected in the cerebellum. We tried paclitaxel administration. It was continued on a weekly basis at 70 mg/m(2), and the brain metastases continued to diminish; in addition, gamma knife therapy led to an improvement in the quality of life. Although the patient had been told that he had only a month to live, he was improving dramatically. However, he died of sepsis due to Fournier's gangrene about 5 months later. Paclitaxel seems to have a strong antineoplastic effect by brain metastasis of gastric cancer.
Download full-text PDF |
Source |
---|
Helicobacter
January 2025
Department of Public Health, University of Otago, Wellington, South, New Zealand.
Background: As seen globally, there are up to sixfold differences in gastric cancer mortality by ethnicity in Aotearoa New Zealand, and H. pylori is the major modifiable risk factor. This study investigates whether current H.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Department of Infectious Diseases, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471000, Henan, China.
Gastrointestinal tumors, including colorectal and liver cancer, are among the most prevalent and lethal solid tumors. These malignancies are characterized by worsening prognoses and increasing incidence rates. Traditional therapeutic approaches often prove ineffective.
View Article and Find Full Text PDFCurr Protein Pept Sci
January 2025
Key Laboratory of Medical Cell Biology in Inner Mongolia, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia,010050, China.
Background: Gastric cancer has become one of the major diseases threatening human health. This study aimed to investigate the mechanism of an anticancer bioactive peptide (ACBP) combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. The therapeutic effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice with human gastric cancer were also investigated.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
September 2023
Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota.
One anastomosis gastric bypass (OAGB) is growing in popularity, although it is potentially associated with biliary gastritis and gastroesophageal reflux esophagitis, with a potential rise in esophageal carcinoma. We describe the surgical management of a 53-year-old man with history of OAGB in whom biliary reflux and esophageal adenocarcinoma developed. We performed a minimally invasive Ivor Lewis esophagectomy, resected the sleeved stomach pouch, created a new conduit out of the remnant greater curve of the remnant stomach with blood supply from an intact gastroepiploic artery, and created an esophagogastric anastomosis.
View Article and Find Full Text PDFJ Cancer Prev
December 2024
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Serological tests for needs local validation as the diagnostic accuracy may vary depending on the prevalence of . . This study examined the diagnostic performance of two ELISA, GastroPanel (GastroPanel ELISA; Biohit Oyj) and GENEDIA (GENEDIA .
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!