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Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei.
Nat Commun
January 2025
University of Glasgow Centre for Parasitology, The Wellcome Centre for Integrative Parasitology, University of Glasgow, School of Infection and Immunity, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, United Kingdom.
The Trypanosoma brucei genome is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes. Additionally, hundreds of sub-megabase chromosomes contain 177 bp repeats of unknown function, and VSG transcription sites localise to many telomeres.
View Article and Find Full Text PDFDevelopment of a short and an ultra-brief version of the Saving Inventory-revised (SI-R) for assessing hoarding severity: The SI-R9 and the SI-R3.
J Psychiatr Res
December 2024
The Cairnmillar Institute, Hawthorn East, VIC, 3123, Australia. Electronic address:
Hoarding Disorder (HD) is marked by the inability to discard possessions, and often excessive acquiring, which results in cluttered living spaces that substantially disrupt daily life. While the Saving Inventory-Revised (SI-R) serves as a reliable and valid tool for assessing hoarding severity, its length may preclude routine use. We aimed to develop a valid shorter version of the scale using Item Response Theory and Confirmatory Factor Analysis in a non-selected sample of 2890 individuals and a clinical HD sample of 200 participants, which were divided into test and confirmatory samples in a 2:1 ratio.
View Article and Find Full Text PDFAUK3 is required for faithful nuclear segregation in the bloodstream form of Trypanosoma brucei.
Mol Biochem Parasitol
February 2025
University of Glasgow, Centre for Parasitology, School of Infection and Immunity, 120 University Place, Sir Graeme Davies Building, Glasgow G12 8TA, United Kingdom. Electronic address:
Eukaryotic chromosomes segregate faithfully prior to nuclear division to ensure genome stability. If segregation becomes defective, the chromosome copy number of the cell may alter leading to aneuploidy and/or polyploidy, both common hallmarks of cancers. In eukaryotes, aurora kinases regulate chromosome segregation during mitosis and meiosis, but their functions in the divergent, single-celled eukaryotic pathogen Trypanosoma brucei are less understood.
View Article and Find Full Text PDFDo tissue-dwelling trypanosomes sustain transmission populations?
Trends Parasitol
January 2025
University of Glasgow Centre for Parasitology, University of Glasgow, School of Infection and Immunity, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK. Electronic address:
Trypanosoma brucei infectious populations are marked by considerable diversity in the parasite's major antigen, the variant surface glycoprotein (VSG). However, most parasites in the bloodstream are non-replicating, questioning how VSG diversity arises. Beaver et al.
View Article and Find Full Text PDFParental mentalization across cultures: Mind-mindedness and parental reflective functioning in British and South Korean mothers.
Infant Ment Health J
December 2024
Department of Psychology, University College Cork, Cork, Ireland.
Differences in mind-mindedness and parental reflective functioning (PRF) were investigated in mothers and their 6-month-old infants from South Korea (N = 66, 32 girls) and the United Kingdom (N = 63, 26 girls). Mind-mindedness was assessed in terms of appropriate and non-attuned mind-related comments during infant-mother interaction; PRF was assessed using a questionnaire. British mothers commented more on infant desires and preferences, whereas Korean mothers commented more on cognitions and emotions, but there were no cultural differences in overall levels of mind-mindedness.
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