Hormone therapy: maximizing the benefits.

Despite the ongoing controversy surrounding the findings from recent studies of hormone therapy (HT) and their implications for its use, HT is indisputably highly beneficial for treating climacteric symptoms and vaginal atrophy and in preventing osteoporosis. An apparent small increase in breast cancer risk with combined HT must be balanced against a reduction in the significant morbidity and mortality associated with fractures, combined with improved well-being, quality of life, and potential protection against colorectal cancer and cardiovascular disease. Individualization of HT regimen and dose depending on the woman's wishes and circumstances appears to be one way to maximize the benefits of HT and minimize the risks.