Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded cross-linked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF02969427 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation.
Mater Today Bio
February 2025
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, 100044, China.
Recent advancements in tissue engineering have promoted the development of nerve guidance conduits (NGCs) that significantly enhance peripheral nerve injury treatment, improving outcomes and recovery rates. However, utilising tailored biomimetic three-dimensional (3D) topological porous structures combined with multiple bio-effect neurotrophic factors to create environments similar to neural tissues, regulate local immune responses, and develop a supportive microenvironment to promote peripheral nerve regeneration and repair poses significant challenges. Herein, a biomimetic extracellular matrix (ECM) NGC featuring an interconnected 3D porous network and sustained delivery of insulin-like growth factor-1 (IGF-1) is designed using multi-functional gelatine microcapsules (GMs).
View Article and Find Full Text PDFThe construction of a double-layer colon-targeted delivery system based on zein-shellac complex and gelatin-isomaltooligosaccharide Maillard product: In vitro and in vivo evaluation.
Food Res Int
January 2025
College of Life Sciences, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Forest Food Resources Utilization of Heilongjiang Province, Harbin 150040, PR China. Electronic address:
In this study, we developed a double-layer colon-targeted microcapsule. It used the Maillard product of gelatin-isomaltooligosaccharide (GI180) and zein-shellac complex (ZS) as bio-based materials, plant extracts (MPL) and Lactobacillus plantarum JJBYG12 (JJBYG12) were co-encapsulated, endowing them with strong resistance to harsh environments and precise intestinal adhesion and targeting ability. The research results indicated that ZS11 exhibits hydrogen bonding and electrostatic interactions.
View Article and Find Full Text PDFCooked germ-remained milled rice presents high stability in water-holding capacity and textural properties during frozen storage-The protection effect of oil-phase reabsorption.
Food Chem
March 2025
School of Food Science and Technology, Jiangnan University, Lihu Avenue 1800, Wuxi 214122, China; State Key Laboratory of Food Science and Resources, Jiangnan University, Lihu Avenue 1800, Wuxi 214122, China; National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Lihu Avenue 1800, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Lihu Avenue 1800, Wuxi 214122, China. Electronic address:
To enhance the stability in textural attributes of frozen cooked rice, this study has found and proposed a new strategy: retaining the rice germ in milling process. Each rice germ is comparable to a native lipid-rich microcapsule attached to the endosperm part. In the gelatinization process, leached germ oil was reabsorbed in the outer layer of rice granule.
View Article and Find Full Text PDFFunctionalized Nanozyme Microcapsules Targeting Deafness Prevention via Mitochondrial Homeostasis Remodeling.
Adv Mater
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225001, China.
Mitochondrial dysfunction, which is the primary mechanism underlying cisplatin-induced hearing loss, can potentially be mitigated by modulating the redox balance and reprogramming the energy metabolism to remodel mitochondrial homeostasis. Herein, N-acetyl-l-cysteine-derived carbonized polymer dots (NAC CPDs) are embedded into manganese porphyrin-doped metal-organic frameworks and encapsulated using a polydopamine (PDA) coating and gelatin methacryloyl (GelMA) hydrogel to afford functionalized nanozyme microcapsules. Owing to their injectability and adhesion properties, these microcapsules exhibit the advantages of prolonged retention in the middle ear and sustained release in the inner ear.
View Article and Find Full Text PDFEmpowering Arthritis Patients: Optimized Drug Delivery through Piroxicam Microcapsule-Embedded Scaffold Implants via Box-Behnken Experimental Design.
Pharm Nanotechnol
December 2024
Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Kattankulathur-603203, Tamil Nadu, India.
Background: The necessity for extended drug discharge to alleviate pain without adverse effects underscores the importance of innovative drug delivery systems. Achieving sustained pain relief without compromising patient safety is a critical objective in healthcare. By extending the duration of drug action while suppressing side effects, such systems offer enhanced therapeutic outcomes and improved patient quality of life.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!