AI Article Synopsis
- A branching strategy was developed to create a natural product-like library featuring a benzopyran motif, aiming to enhance the complexity and diversity of the resulting chemical compounds.
- The research emphasizes the significance of varying skeletal structures based on a privileged substructure to improve drug-like properties.
- Biological evaluations showed that a small molecule library, comprised of 22 different core structures, was effective when tested for cytotoxicity in vitro.
Article Abstract
A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.
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| http://dx.doi.org/10.1039/b606341a | DOI Listing |
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