Objective: The objective of this study was to determined if there was a relationship between Grover's disease and Parkinson disease.
Methods: Fourteen patients with Parkinson disease and 14 control patients were randomly selected and examined for cutaneous eruptions and blood mercury levels.
Results: Of the 14 patients with Parkinson's disease, 13 had Grover's disease and detectable blood mercury. None of the patients in the control group had a cutaneous eruption and only 2of the 14 had detectable blood mercury.
Conclusion: Mercury may play a role in the etiology of Parkinson disease and Grover's disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.jom.0000228351.74230.52 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Grover's disease-like patterns in early pityriasis rubra pilaris.
J Dtsch Dermatol Ges
November 2024
Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
Grover's disease in oncologic patients: clinicopathologic features and systematic review.
Int J Dermatol
October 2024
Unit of Dermatology, IRCCS Ospedale San Raffaele, Milano, Italy.
ERK hyperactivation in epidermal keratinocytes impairs intercellular adhesion and drives Grover disease pathology.
JCI Insight
November 2024
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Article Synopsis
- Grover disease is a skin condition characterized by blistering caused by the breakdown of connections between skin cells, with its causes still unknown and no FDA-approved treatment available.
- Research has shown that B-RAF inhibitors used in cancer treatment can paradoxically lead to Grover disease by causing hyperactivation of ERK, which disrupts skin cell cohesion.
- The study suggests that inhibiting MEK can prevent the onset of Grover disease by controlling ERK activation, indicating a potential therapeutic approach that could benefit both Grover disease and similar genetic conditions like Darier disease.
Corrigendum to A Case of Grover's Disease Secondary to Brodalumab Therapy for Psoriasis.
J Psoriasis Psoriatic Arthritis
October 2023
Article Synopsis
- The article DOI: 10.1177/2475530320970530 has been amended to address inaccuracies or errors found in the original work.
- The corrections made aim to improve the clarity and credibility of the information presented.
- Readers are encouraged to refer to the updated article for the most accurate and reliable content.
Grover's Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?
Int J Mol Sci
September 2024
Pathophysiology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Article Synopsis
- * There is a noted but poorly defined connection between GD and cutaneous keratinocyte carcinomas, specifically non-melanoma skin cancers (NMSCs), with very few studies highlighting this relationship between 1983 and 2024.
- * GD has been misdiagnosed as various NMSCs, and understanding this connection could provide insights into its underlying mechanisms, possibly reclassifying GD as a unique syndrome.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!