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Fungal Infections Associated With TNF-Inhibitors: A 20-Year of a Systematic Review Fungal Infections and TNF-Inhibitors.
Mycoses
March 2025
Faculdade de Ciências da Saúde (FCS), Rodovia Dourados/Itahum, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
TNF-α inhibitors, including infliximab, adalimumab and etanercept, are used to treat various inflammatory diseases, such as arthritis, psoriasis and ankylosing spondylitis. However, these treatments may predispose patients to fungal infections, including histoplasmosis, candidiasis and aspergillosis. In this study, we systematically reviewed case reports to critically examine the correlations between anti-TNF-α therapies and the occurrence of invasive and superficial fungal infections.
View Article and Find Full Text PDFRisk of hematologic malignancies in psoriasis and rheumatoid arthritis patients using long term TNF-α inhibitors: a retrospective nationwide study.
Sci Rep
March 2025
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.
This retrospective cohort study included all user of tumor necrosis factor-α inhibitors (TNFi), including etanercept, infliximab, adalimumab, and golimumab, among Korean patients with psoriasis and rheumatoid arthritis (N of user = 7,645) and the non-user who was diagnosed with same diseases, never used TNFi, and was served as the reference. Cumulative usage of TNFi was calculated between the newly diagnosed date and index date (2-year from the diagnosed date). Adjusted hazard ratio (aHR [95% confidence intervals (CIs)]) for colorectal, liver, lung, kidney, breast, and thyroid cancer were not significantly increased or decreased: 0.
View Article and Find Full Text PDFComparison of the Efficacy and Safety of Disease-Modifying Antirheumatic Drugs Combination Therapies: A Systematic Review and Network Meta-Analysis.
Clin Transl Sci
March 2025
Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
There are several disease-modifying antirheumatic drugs currently available to treat rheumatoid arthritis (RA). However, the optimal combination therapy with methotrexate for treating RA remains unclear. We aimed to identify combination therapies with high-efficacy and safety by employing the Bayesian method in a network meta-analysis.
View Article and Find Full Text PDFManaging Hidradenitis Suppurativa with Biologics and Small Molecule Inhibitors.
Dermatol Clin
April 2025
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, PCAM 7 South, Room 724, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:
"Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a significant quality-of-life impact. In addition to the 2 drugs approved by the Food and Drug Administration for HS, adalimumab and secukinumab, several other biologic and small molecule inhibitors are used off-label or are in clinical trials. A systematic and evidence-based approach using these and other therapies-considering patient comorbidities, response to therapy, dose adjustment, and frequent troubleshooting-is required.
View Article and Find Full Text PDFBiological Agents' Adverse Events in Jordanian Childhood Rheumatic Diseases: A Single-Center Experience.
Cureus
January 2025
Immunology, Allergy and Rheumatology, Royal Medical Services, Queen Rania Children's Hospital, Amman, JOR.
Rheumatic diseases encompass a heterogeneous group of autoimmune and autoinflammatory disorders affecting joints, muscles, and connective tissue, with juvenile idiopathic arthritis (JIA) being the most prevalent among children. The introduction of biological agents in the treatment of childhood rheumatic diseases has significantly improved outcomes and quality of life. However, there is limited data on the use of biological agents in Jordanian children with these conditions.
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