Objective: To investigate the expression of galectin-3 in benign and malignant thyroid nodules.
Methods: Galectin-3 expression was assayed with immunohistochemical and RT-PCR methods in thyroid specimens.
Results: The majority of the specimens of thyroid carcinomas expressed galectin-3 with immunohistochemical and RT-PCR methods (89.7% and 91.7%) and the expression was significantly in different histological types. Papillary and follicular thyroid malignancies showed high expression of galectin-3 (100% positive). Comparing the specimens of thyroid carcinomas with metastases and those without metastases, the expression of galectin-3 was significantly higher in the former than in the latter. Among 25 specimens of benign adenomas and 13 specimens of nodular hyperplasia, only 3 were weakly positive and other were negative. Neither 10 specimens of normal thyroid tissue nor 25 specimens of paracarcinomatous thyroid tissue expressed galectin-3.
Conclusion: Galectin-3 may be used as a marker for differentiating benign and malignant thyroid nodules.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Microglial galectin-3 increases with aging in the mouse hippocampus.
Korean J Physiol Pharmacol
January 2025
Department of Anatomy and Convergence Medical Science, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.
Microglial activation during aging is associated with neuroinflammation and cognitive impairment. Galectin-3 plays a crucial role in microglial activation and phagocytosis. However, the role of galectin-3 in the aged brain is not completely understood.
View Article and Find Full Text PDFBcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma.
Dent Res J (Isfahan)
December 2024
Department of Restorative Dentistry, College of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
Background: Ameloblastoma is a benign odontogenic neoplasm with a high recurrence rate. Identifying cellular and molecular changes in this neoplasm may help predict the recurrence risk. Bcl-2 and galectin-3 are anti-apoptotic proteins associated with the prognosis of many neoplasms.
View Article and Find Full Text PDFGalectin-1 and galectin-3 in male reproduction - impact in health and disease.
Semin Immunopathol
January 2025
Institute of Anatomy and Cell Biology, Hessian Centre of Reproductive Medicine, Justus-Liebig University Giessen, Aulweg 123, 35392, Giessen, Germany.
The formation and differentiation of mature, motile male germ cells, which can fertilize the egg and ensure successful implantation and development of a healthy embryo, are essential functions of the testis and epididymis. Spermatogenesis is a complex, multistep process that results in the formation of motile haploid gametes, requiring an immunoregulatory environment to maintain tolerance to developing neo-antigens. Different cell types (Sertoli cells, macrophages), immunoregulatory factors and tolerance mechanisms are involved.
View Article and Find Full Text PDFSecreted LGALS3BP facilitates distant metastasis of breast cancer.
Breast Cancer Res
January 2025
College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Background: Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the patients who have initially been treated. Secreted proteins from tumors play important roles in cancer metastasis but previous methods for isolating secretory proteins had limitations in identifying novel targets.
Methods: We applied an in situ secretory protein labeling technique using TurboID to analyze secretome from tamoxifen-resistant (TAMR) BC.
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma.
FEBS J
January 2025
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada.
In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correlation between PANX1 mRNA and core Hippo components, Yes-associated protein 1 [YAP], Transcriptional coactivator with PDZ-binding motif [TAZ], and Hippo scaffold, Ras GTPase-activating-like protein IQGAP1 [IQGAP1], in invasive cutaneous melanoma and breast carcinoma. Furthermore, we demonstrated that PANX1 expression is upregulated in invasive melanoma cell lines and is associated with increased YAP protein levels.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!