According to the structural characteristics of spiral CT systems and our experiences, some relevant solutions to common malfunctions in daily maintenance are suggested.
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Chiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications.
Biotechnol Adv
January 2025
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. Electronic address:
In nature, various molecules possess spiral geometry. Such helical structures are even prevalent within the human body, represented classically by DNA and three-dimensional (secondary structure) protein folding. In this review, we chose helicenes and helicene-like structures -synthetically accessible carbon-rich molecules- as a compelling example of helically chiral scaffolds.
View Article and Find Full Text PDFHydrogel injection molded complex macroencapsulation device geometry improves long-term cell therapy viability and function in the rat omentum transplant site.
Biomaterials
December 2024
School of Biological and Health Systems Engineering, Arizona State University, 550 East Orange St., Tempe, AZ, 85281, USA. Electronic address:
Insulin-secreting allogeneic cell therapies are a promising treatment for type 1 diabetes, with the potential to eliminate hypoglycemia and long-term complications of the disease. However, chronic systemic immunosuppression is necessary to prevent graft rejection, and the acute risks associated with immunosuppression limit the number of patients who can be treated with allogeneic cell therapies. Islet macroencapsulation in a hydrogel biomaterial is one proposed method to reduce or eliminate immune suppression; however, macroencapsulation devices suffer from poor oxygen transport and limited efficacy as they scale to large animal model preclinical studies and clinical trials.
View Article and Find Full Text PDFWavebreakers in excitable systems and possible applications for corrosion mitigation.
Chaos
January 2025
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA.
Traveling waves of excitation arise from the spatial coupling of local nonlinear events by transport processes. In corrosion systems, these electro-dissolution waves relay local perturbations across large portions of the metal surface, significantly amplifying overall damage. For the example of the magnesium alloy AZ31B exposed to sodium chloride solution, we report experimental results suggesting the existence of a vulnerable zone in the wake of corrosion waves where local perturbations can induce a unidirectional wave pulse or segment.
View Article and Find Full Text PDFEffective Spiral Laser Path for Minimizing Local Heating and Anisotropic Microstructures in Powder Bed Fusion Additive Manufacturing.
3D Print Addit Manuf
December 2024
School of Mechanical Engineering, Pusan National University, Busan, Korea.
Heat accumulation due to repetitive simple laser processing paths during building up a three-dimensional structure is a well-known issue that needs to be settled to reduce the excessively high residual stress and thermal deformation in a powder bed fusion (PBF) additive manufacturing process. Because of the dependency of laser path on the thermal dispersion, it is essential to analyze the heat accumulation phenomenon during laser processing. A computational fluid dynamics (CFD) analysis based on the volume of fraction method is used to optimize the laser path for minimizing the local heating up in the PBF process.
View Article and Find Full Text PDFBlue Light-Induced, Dosed Protein Expression of Active BDNF in Human Cells Using the Optogenetic CRY2/CIB System.
Biotechnol J
December 2024
Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
The use of optogenetic tools offers an excellent method for spatially and temporally regulated gene and protein expression in cell therapeutic approaches. This could be useful as a concomitant therapeutic measure, especially in small body compartments such as the inner ear, for example, during cochlea implantation, to enhance neuronal cell survival and function. Here, we used the blue light activatable CRY2/CIB system to induce transcription of brain-derived neurotrophic factor (BDNF) in human cells.
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