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Validation and psychometric properties of the bipolar prodrome symptom interview and scale-full prospective Chinese version to assess individuals at risk for bipolar disorder.
J Affect Disord
February 2025
The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA; Charité - Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; German Center for Mental Health (DZPG), partner site Berlin, Germany.
Background: Bipolar disorder (BD) is a chronic, severe mental illness with a significant socio-economic burden. The early recognition of BD requires reliable and valid instruments.
Objective: We evaluated the psychometric attributes of the Bipolar Prodrome Symptom Interview and Scale-Full Prospective (BPSS-FP)-Chinese version.
2D Nitrogen-Doped Graphene Materials for Noble Gas Separation.
Small
November 2024
Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, Šlechtitelů 27, Olomouc, 783 71, Czech Republic.
Noble gases, notably xenon, play a pivotal role in diverse high-tech applications. However, manufacturing xenon is an inherently challenging task, due to its unique properties and trace abundance in the Earth's atmosphere. Consequently, there is a pressing need for the development of efficient methods for the separation of noble gases.
View Article and Find Full Text PDFHyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice.
J Vis Exp
October 2024
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center; Department of Biomedical Engineering, University of Cincinnati; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center;
Article Synopsis
- Hyperpolarized xenon-129 (Xe) is a specialized MRI contrast agent that helps measure various aspects of lung function, making it useful for diagnosing and tracking lung diseases in humans.
- It is approved for clinical use in places like the U.S. and U.K. and offers noninvasive ways to study lung health in preclinical research settings, particularly with mice, which are commonly used in genetic studies.
- The text outlines practical procedures and checklists for effectively using Xe MRI in animal studies, focusing on ensuring accurate data collection related to lung disease monitoring.
Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.
Brain Commun
October 2024
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Article Synopsis
- In medication-resistant epilepsy, surgery aims to achieve seizure freedom while minimizing harm through careful planning based on electroclinical data and neuroimaging techniques.
- A support vector machine (SVM) was utilized to analyze fast ripple (FR) metrics from patients, achieving a prediction accuracy of 78% for effective surgical resections.
- Simulations indicated that larger virtual resections often led to improved seizure freedom outcomes, suggesting that targeting high-frequency oscillations may enhance surgical success rates.
Long-term safety and efficacy of adjunctive lacosamide in the treatment of generalized onset tonic-clonic seizures: An open-label extension trial.
Epilepsia
December 2024
Department of Neurosciences, School of Translational Medicine, Monash University and Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Objective: This study was undertaken to assess long-term safety, tolerability, and efficacy of lacosamide (LCM) as adjunctive therapy for generalized onset tonic-clonic seizures (GTCS) in patients aged ≥4 years with idiopathic generalized epilepsy (IGE).
Methods: EP0012 (NCT02408549) was a phase 3, multicenter, open-label extension (OLE) trial. Patients were enrolled from SP0982 (NCT02408523).
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