AI Article Synopsis
- The study aimed to examine cognitive outcomes in patients undergoing on-pump versus off-pump coronary artery bypass grafting.
- The research involved 70 patients and included standardized neuropsychological tests to assess various cognitive functions and levels of anxiety and depression before and after surgery.
- Results indicated no significant differences in cognitive impairment, anxiety, or depression between the two groups at various post-operative time points, suggesting similar outcomes for both types of surgery.
Article Abstract
Objective: To investigate cognitive outcome after on and off pump coronary artery bypass grafting.
Methods: Seventy patients between 50 and 80 years with stable angina pectoris, ejection fraction >30%, serum creatinine <150 micromol/l, and lack of tight main stem stenosis were randomized to on or off pump coronary artery bypass grafting. Standardized neuropsychological tests evaluated attention, verbal and visuo-spatial short-term and working memory, verbal learning, delayed recall, visuo-motor speed, and aspects of executive functions. Levels of anxiety and depression were also investigated. Testing was performed before and at 1 week, 1 and 6 months after surgery.
Results: There was no difference in cognitive impairment (defined as a 20% reduction in at least 20% of the tests) between groups. The incidence at 1 week post-operatively was 57% in the on pump group and 58% in the off pump group, after 1 month 30% and 12% and after 6 months 19% and 15%, respectively (p for interaction=0.19). There was no difference between groups in anxiety (p=0.18) or depression (p=0.48).
Conclusions: This prospective, randomized study showed no differences in post-operative cognitive function after on pump compared to off pump coronary artery bypass grafting in low risk patients.
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| http://dx.doi.org/10.1016/j.ejcts.2006.03.037 | DOI Listing |
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