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Signaling via retinoic acid receptors mediates decidual angiogenesis in mice and human stromal cell decidualization.
FASEB J
January 2025
Department of Obstetrics, Gynecology and Reproductive Health, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
At the maternal-fetal interface, tightly regulated levels of retinoic acid (RA), the physiologically active metabolite of vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human cells, and pharmacological tools to demonstrate how depletion of RA signaling via RA receptor (RAR) disrupts implantation and progression of early pregnancy. To inhibit RAR signaling during early pregnancy, BMS493, an inverse pan-RAR agonist that prevents RA-induced differentiation, was administered to pregnant mice during the peri-implantation period.
View Article and Find Full Text PDFQuercetin Alleviates All--Retinal-Induced Photoreceptor Apoptosis and Retinal Degeneration by Inhibiting the ER Stress-Related PERK Signaling.
Int J Mol Sci
December 2024
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China.
All--retinal (atRAL)-induced photoreceptor atrophy and retinal degeneration are hallmark features of dry age-related macular degeneration (AMD) and Stargardt disease type 1 (STGD1). The toxicity of atRAL is closely related to the generation of reactive oxygen species (ROS). Quercetin, a natural product, is known for its potent antioxidant properties; however, its effects in mitigating atRAL-mediated retinal damage remains unclear.
View Article and Find Full Text PDFIntegrating Dermocosmetic Therapy for Acne: Addressing Severity Levels in Real-Life Experiences.
J Drugs Dermatol
January 2025
Background: Acne is prevalent in approximately 80% of individuals aged 11 to 30 years, with scarring occurring in about 40% of cases. Early and sustained treatment is crucial for preventing acne scarring, regardless of severity.
Objectives: The objective of this study was to evaluate skin tolerability and patient compliance after combining a specific dermatologic routine with pharmacological therapy in patients affected by different degrees of acne.
Maintenance Acne Treatment with Topical Tazarotene after Oral Isotretinoin: Overview and Case Reports.
J Clin Aesthet Dermatol
January 2024
Ms. Miranti is with Riverchase Dermatology and Cosmetic Surgery in Naples, Florida.
Acne is a chronic dermatologic disorder that can require long-term treatment. To prevent recurrence after oral treatment for severe acne, topical maintenance treatment is recommended; however, there is little guidance or research on maintenance regimens. This article briefly summarizes literature on oral isotretinoin and topical retinoids and presents a case series of patients who received tazarotene 0.
View Article and Find Full Text PDFOral Isotretinoin-Associated Ocular Effects and Risk Factors: A Cross-Sectional Study.
Clin Ophthalmol
December 2024
Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Article Synopsis
- This study examines the effects of oral isotretinoin on eye health in patients with acne vulgaris, highlighting issues like dryness and discomfort.
- A survey of 489 participants showed a high prevalence of ocular symptoms linked to isotretinoin use, with notable findings including a majority experiencing soreness and blurred vision.
- Key risk factors for worsening eye symptoms included contact lens use and higher isotretinoin dosages, suggesting the need for careful monitoring and preventive measures for patients at risk.
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