Objectives: The objective of this study was to investigate how the expression of the RANK-RANKL-OPG system mediates the formation and differentiation of osteoclasts and causes bone resorption in cholesteatoma.
Methods: An immunohistochemical analysis was carried out in 22 cholesteatoma tissues obtained during middle ear surgery and 15 normal postauricular skin tissues to examine the expression of RANKL and OPG.
Results: All 22 cases of cholesteatoma and the 15 cases of normal postauricular skin expressed RANKL and OPG. The count and rate of RANKL-positive cells in cholesteatoma was significantly higher than in normal postauricular skin. The count and rate of OPG-positive cells in normal postauricular skin was significantly higher than in cholesteatoma. The ratio of the positive expression rates of RANKL and OPG in cholesteatoma was statistically higher than in normal postauricular skin.
Conclusions: We provide evidence suggesting that RANKL, which activates osteoclasts, plays a significant role in the mechanism of bone destruction in cholesteatoma, and that the ratio of RANKL to OPG may be a reliable indicator of bone destruction in cholesteatoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.mlg.0000224345.59291.da | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Silent otitis media with multiple intracranial complications.
BMJ Case Rep
December 2024
Department of Otorhinolaryngology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth- Deemed to be-University, Pondicherry, India.
Article Synopsis
- A 40-year-old man with no prior health issues presented with a 5-day history of swelling behind his right ear, along with a previous episode of ear pain two months earlier.
- Examination and imaging revealed right otomastoiditis, which is an infection of the mastoid bone, along with serious complications like a bony defect and brain abscesses.
- After starting intravenous antibiotics and undergoing surgery to drain the abscess, he had a cortical mastoidectomy three weeks later and has had no further health complaints during regular follow-ups over the past six months.
Correction of Microtia with Constricted Ear Features Using Helix Costal Cartilage Scaffold and Postauricular Flap Advancement.
Plast Reconstr Surg
November 2024
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing, China.
Background: Microtia with constricted ear features represents a challenging congenital deformity characterized by the variable shape and large volume of the remnant cartilage and skin involved. This study aims to evaluate the efficacy and safety of a method using helix costal cartilage scaffold and postauricular flap advancement for the correction.
Methods: This retrospective study analyzed the clinical and postoperative data of 121 patients diagnosed with microtia and constricted ear features, treated at our institution between January 2020 and January 2023.
An Atypical Occurrence of Epidermoid Cyst in the Postauricular Parotid Region of a Young Child: A Case Report and Literature Review.
Cureus
September 2024
Department of Pedodontics and Preventive Dentistry, Hitkarini Dental College and Hospital, Jabalpur, IND.
Benign epidermal cysts, also called epidermoid cysts, can sometimes develop in the orofacial region from trapped epidermal components without skin adnexal appendages. Congenital or acquired conditions could be the case. Epidermoid cysts have been found to occur in 6.
View Article and Find Full Text PDFEar Reconstruction for Auricle Defects Using an Expanded Neck Flap: A Case Report.
Ear Nose Throat J
October 2024
Department of Plastic & Laser Cosmetology, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, China.
Article Synopsis
- - A patient with a left ear deformity from a flame burn received a 3-stage reconstruction using an expanded neck flap and rib cartilage as the framework for the ear.
- - The reconstruction involved implanting tissue expanders, excising scar tissue, and using the expanded flap to cover the ear framework, followed by final shaping and scar removal.
- - After one year, the reconstruction healed well with minor complications, resulting in a realistic ear shape and improved appearance, suggesting that expanded neck flaps can be an effective solution for burn patients with limited flap options.
mA modification of lncRNA in middle ear cholesteatoma.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2024
Department of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Objectives: Middle ear cholesteatoma is a non-tumorous condition that typically leads to hearing loss, bone destruction, and other severe complications. Despite surgery being the primary treatment, the recurrence rate remains high. Therefore, exploring the molecular mechanisms underlying cholesteatoma is crucial for discovering new therapeutic approaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!