Carbohydrate antigen detection, nucleic acid probe detection, and bacterial culture are commonly used to confirm group A streptococcus (GAS) pharyngitis. Compared to standard throat swab specimens, the sensitivities of these tests with mouth specimens are poor. When testing for GAS pharyngitis, the throat remains the optimum site for sampling.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489465 | PMC |
http://dx.doi.org/10.1128/JCM.00797-06 | DOI Listing |
Expert Rev Mol Diagn
December 2024
Scientific Affairs, Cepheid, Sunnyvale, CA, USA.
Introduction: Rapid and accurate detection of group A (GAS) pharyngitis allows for timely initiation of appropriate antibiotic treatment. This is important to prevent empiric antibiotic overuse while simultaneously lowering the risk of post-infection sequelae. Timely treatment may also reduce forward transmission, which could prevent cases of devastating invasive infections.
View Article and Find Full Text PDFCureus
November 2024
Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu, JPN.
, also known as group A (GAS), is responsible for various conditions, such as pharyngitis, tonsillitis, necrotizing fasciitis, and streptococcal toxic shock syndrome (STSS). STSS, a rapidly progressing infection involving shock and multi-organ failure, was first reported in Japan in 1992, and since then, the number of cases has been steadily increasing. We herein report an autopsy case of STSS that resulted in sudden death.
View Article and Find Full Text PDFInt J Cardiol Cardiovasc Risk Prev
June 2024
Department of Child Health, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria.
The prevention and treatment of Rheumatic Heart disease is hinged on antibiotic administration in children with Group A (GAS) pharyngitis and Acute Rheumatic Fever (ARF). The Upper Limit of Normal (ULN) for serum Anti-streptolysin O titre (ASOT) has been employed as proof of antecedent GAS pharyngitis to fulfil the Jones' criteria for diagnosis of ARF. This value has not been generated among West African children.
View Article and Find Full Text PDFN Z Med J
December 2024
Clinical Microbiologist, Microbiology/Molecular Departments, Medlab Central, Palmerston North.
Aim: This work describes the validation of an in-house extraction free real-time polymerase chain reaction (PCR) for the detection of Group A Streptococcus (GAS) in throat swabs collected in gel amies.
Method: Throat swabs received by the laboratory were prospectively tested by routine bacterial culture and an in-house PCR assay targeting the GAS SpeB gene with a multiplexed RNaseP internal control. Samples with discrepant culture/PCR results had additional testing using the commercial Xpert Group A Strep PCR assay (Cepheid).
Cureus
October 2024
Internal Medicine, Hospital São Teotónio, Viseu, PRT.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!