AI Article Synopsis
- The study examined how amphotericin B in an emulsion formulation affects kidney cell monolayer integrity.
- The conventional formulation, Fungizone, damaged the cells at concentrations above 1 microgram mL-1, while the emulsion showed no negative effects even at 100 micrograms mL-1.
- The emulsion maintained similar antifungal effectiveness against Saccharomyces cerevisiae as Fungizone, indicating it might be less toxic and more therapeutically beneficial.
Article Abstract
The effect of amphotericin B in an emulsion formulation on the integrity of monolayers of kidney cells has been studied. Whereas a conventional solubilized amphotericin formulation (Fungizone, Squibb) caused a loss in monolayer integrity at concentrations above 1 microgram mL-1, the emulsion formulation had no measurable effect on confluence at amphotericin concentrations up to 100 micrograms mL-1. The emulsion retained a comparable antifungal activity to that of Fungizone against Saccharomyces cerevisiae in suspension culture. These results parallel the observed erythrocyte lysis data obtained previously using amphotericin B emulsions, and suggest that the emulsion formulation may have a lower toxicity and improved therapeutic potential over existing formulations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.2042-7158.1991.tb03529.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!