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Adherence and persistence to tafamidis treatment among Medicare beneficiaries in the presence of a patient assistance program.
Sci Rep
July 2024
Pfizer Inc, New York, NY, USA.
Tafamidis is the only disease-modifying therapy approved to treat patients in the United States with transthyretin amyloid cardiomyopathy (ATTR-CM), which most commonly affects patients aged ≥ 65 years. The manufacturer operates a patient assistance program (PAP) to support access to tafamidis. This study conducted Privacy Preserving Record Linking (PPRL) using Datavant tokens to match patients across Medicare prescription drug plan (PDP) and PAP databases to evaluate the impact of PAPs on treatment exposure classification, adherence, and persistence determined using Medicare PDP data alone.
View Article and Find Full Text PDFDiagnostic performance of plasma pTau, pTau, Aβ and Aβ in the LUMIPULSE automated platform for the detection of Alzheimer disease.
Alzheimers Res Ther
June 2024
Sant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, C/Sant Quintí 89, 08041, Barcelona, Spain.
Article Synopsis
- Recent advances in blood markers for Alzheimer's disease detection show high accuracy, but their practicality in clinical settings remains uncertain due to the need for sensitive equipment.
- A study of 290 participants at a specialized memory clinic revealed that plasma pTau levels were significantly higher in those with amyloid-positive results compared to amyloid-negative individuals, indicating potential for blood tests in diagnosis.
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Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR).
Circulation
September 2024
Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York-Presbyterian Hospital, NY (A.L., G.M., E.D., T.M., M.M., A.J.E., D.K., S.H., Q.L., V.A., M. Lebehn, M. Leon, R.H., P.E., T.J.P.).
Article Synopsis
- A novel deep learning (DL) system was developed to enhance the interpretation of transthoracic echocardiography (TTE) for assessing the severity of mitral regurgitation (MR) by integrating multiple video assessments.
- The system was tested with a large dataset (over 61,000 TTEs) and showed high accuracy in classifying MR severity, achieving exact accuracy rates of 82% for internal and 79% for external test sets.
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Background: Recently developed blood markers for Alzheimer's disease (AD) detection have high accuracy but usually require ultra-sensitive analytic tools not commonly available in clinical laboratories, and their performance in clinical practice is unknown.
Methods: We analyzed plasma samples from 290 consecutive participants that underwent lumbar puncture in routine clinical practice in a specialized memory clinic (66 cognitively unimpaired, 130 participants with mild cognitive impairment, and 94 with dementia). Participants were classified as amyloid positive (A+) or negative (A-) according to CSF Aβ/Aβ ratio.
Comparison of cardio-focal and chest reconstruction of technetium-99m pyrophosphate scintigraphy for diagnosis of transthyretin cardiac amyloidosis: a quality assurance study.
J Nucl Cardiol
December 2023
Division of Cardiology, Cook County Health, Chicago, IL, USA.
Background: SPECT improves diagnostic specificity of Technetium-99m pyrophosphate (PYP) scintigraphy. Diagnostic performance of PYP data, reconstructed as either chest or cardio-focal SPECT is not known.
Methods: In this quality assurance study, blinded evaluation of PYP SPECT/CT data from 102 Caucasian patients (mean age 76 ± 11 years, 67% men) was performed by two readers.
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