AI Article Synopsis
- Non-ulcer dyspepsia is a common issue related to slow stomach movement, and current medications have safety concerns.
- Itopride is a new, safer medication that works by blocking dopamine D2 receptors and inhibiting acetylcholinesterase to improve gastric motility.
- The ENGIP-II study found that itopride significantly reduced various symptoms of non-ulcer dyspepsia and was well-tolerated, suggesting it might be the preferred treatment option.
Article Abstract
Non-ulcer dyspepsia is a common clinical disorder characterised by reduced gastric motility. Safety concerns have restricted use of currently available prokinetic drugs. Itopride is a new safer prokinetic drug with dopamine D2 antagonism and acetylcholinesterase inhibitory actions. The ENGIP-II study was conducted to investigate the efficacy, and safety of itopride in patients of non-ulcer dyspepsia. There were significant reductions in upper abdominal pain, heartburn frequency, gastro-oesophageal regurgitation, nausea, bloating, early satiety after meals at day 3 only; whereas significant improvements were noted in belching, anorexia at day 6 and in vomiting at day 9. Thus, ENGIP-II study shows that itopride was well tolerated patients and appears to be the drug of choice in patients with non-ulcer dyspepsia.
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