AI Article Synopsis
- Fossilia Mastodi OSSIS, a skeletal fossil from an ancient Mastodon, exhibits potential anxiolytic (anxiety-reducing), sedative, and anticonvulsant properties in Oriental medicine.
- In a study, mice treated with an 80% methanol extract showed significant reductions in anxiety, increased sleep duration when combined with pentobarbital, decreased physical activity, and anticonvulsive effects.
- The study indicates that Fossilia's sedative effects may be linked to its action on GABA(A) receptors, suggesting it contains biologically active compounds that could be useful in developing natural sedatives.
Article Abstract
Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic information for the development of a putative natural sedative. The 80% methanol extract of Fossilia Mastodi OSSIS given per os at a dose of 3 g/kg in mice showed anxiolysis, potentiation of pentobarbital sleeping time, reduced locomotor activity, and anticonvulsive activity. Fossilia elicited GABA(A) receptor-mediated anxiolysis. The data obtained suggest that the 80% methanol extract of Fossilia Mastodi OSSIS contains some biologically active principles with sedative activity.
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| http://dx.doi.org/10.1248/bpb.29.1414 | DOI Listing |
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