Peripheral lymphocyte subsets--T-helper (CD4+), T-suppressor/cytotoxic (CD8+), and naive/virgin T cells/natural killer cells (CD45RA)--were studied quantitatively in 30 patients with recurrent aphthous ulceration (RAU) and 29 sex- and age-matched RAU-free control donors. The CD4+ percentage was significantly lower in the patients than in the control group (P less than 0.0001), whereas CD8+ and CD4/CD8 ratio figures did not differ significantly between patients and controls. The CD45RA+ counts were significantly higher in the patient group (P less than 0.01). The study supports previous investigations with regard to the demonstration of immunologic disturbances in RAU patients. Whether the imbalance is primary or secondary with regard to the basic etiology remains to be resolved.

Download full-text PDF

Source
http://dx.doi.org/10.3109/00016359109005908DOI Listing

Publication Analysis

Top Keywords

peripheral lymphocyte
8
recurrent aphthous
8
aphthous ulceration
8
lymphocyte subpopulations
4
subpopulations recurrent
4
ulceration peripheral
4
lymphocyte subsets--t-helper
4
subsets--t-helper cd4+
4
cd4+ t-suppressor/cytotoxic
4
t-suppressor/cytotoxic cd8+
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!