Objective: To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.
Study Design: Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.
Results: Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappaB in all cell lines used.
Conclusion: These results suggest that calcium mobilization and NF-kappaB dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
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| http://dx.doi.org/10.1016/j.ejogrb.2004.07.030 | DOI Listing |
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