A simulation model of the western corn rootworm, Diabrotica virgifera virgifera LeConte, was used to investigate whether sampling and economic thresholds can improve integrated pest management (IPM) and insect resistance management (IRM) when transgenic insecticidal crops are used for insect pest management. When transgenic corn killed at least 80% of susceptible larvae, the calculated economic threshold increased linearly as the proportion of susceptible beetles surviving the toxin increased. The use of economic thresholds slightly slowed the evolution of resistance to transgenic insecticidal crops. In areas with or without rotation-resistant western corn rootworm phenotypes, the use of sampling and economic thresholds generated similar returns compared with strategies of planting transgenic corn, Zea mays L., every season. Because transgenic crops are extremely effective, farmers may be inclined to plant transgenic crops every season rather than implementing costly and time-consuming sampling protocols.
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http://dx.doi.org/10.1603/0022-0493-99.3.899 | DOI Listing |
Cancers (Basel)
December 2024
Faculty of Pharmacy, University of Montreal, 2940 Chem. de Polytechnique, Montreal, QC H3T 1J4, Canada.
Background/objectives: Through phase III clinical trials, PARP inhibitors have demonstrated outcome improvements in mCRPC patients with alterations in BRCA1/2 genes who have progressed on a second-generation androgen receptor pathway inhibitor (ARPI). While improving outcomes, PARP inhibitors contribute to the ever-growing economic burden of PCa. The objective of this project is to evaluate the cost-effectiveness of PARP inhibitors (olaparib, rucaparib, or talazoparib) versus the SOC (docetaxel or androgen receptor pathway inhibitors (ARPI)) for previously progressed mCRPC patients with BRCA1/2 mutations from the Canadian healthcare system perspective.
View Article and Find Full Text PDFTrials
January 2025
Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: A key challenge for many critical care clinical trials is that some patients will die before their outcome is fully measured. This is referred to as "truncation due to death" and must be accounted for in both the treatment effect definition (i.e.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Hebei Orthopaedic Research Institute, Hebei Medical University Third Hospital, No.139 Ziqiang Road, Shijiazhuang, 050051, P.R. China.
Objective: The postoperative recovery of patients with lumbar disc herniation (LDH) requires further study. This study aimed to establish and validate a predictive model for functional recovery in patients with LDH and explore associated risk factors.
Method: Patients with LDH undergoing PLIF admitted from January 1, 2018 to December 31, 2022 were included, and patient data were prospectively collected through follow-up.
Sci Rep
January 2025
School of Physics, Ningxia University, Yinchuan, 750021, China.
Optimizing the installation parameters of photovoltaic panels in a photovoltaic array to reduce dust accumulation, thereby enhancing their power generation, is a crucial research topic in the construction of solar power stations in desert regions. Utilizing a series of wind tunnel experiments on a photovoltaic array comprising four equally sized panels, this study assessed how variations in tilt angle, mounting height, spacing, and incoming flow direction influence both the accumulation mass of dust and the particle size distribution in a photovoltaic array. The results indicate that the dust accumulation on the first panel exponential growth with increasing tilt angle, incoming flow angles, and height, while subsequent panels displayed a trend of initial increase followed by a decrease, with a maximum increasing ratio achieved at specific installation configurations, the difference of dust mass on each panel can even be several times.
View Article and Find Full Text PDFJAMA Health Forum
January 2025
Department of Health Systems, Management, and Policy, University of Colorado Cancer Center, Aurora.
Importance: Medicare Advantage (MA) plans are designed to incentivize the use of less expensive drugs through capitated payments, formulary control, and preauthorizations for certain drugs. These conditions may reduce spending on high-cost therapies for conditions such as cancer, a condition that is among the most expensive to treat.
Objective: To determine whether patients insured by MA plans receive less high-cost drugs than those insured by traditional Medicare (TM).
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