Purpose: To investigate the prevalence and distribution of marginal bone loss in the Danish population.
Materials And Methods: Six hundred and sixteen randomly selected Danish adults (304 females and 312 males), mean age of 42 years (range 21-63 years) underwent a full-mouth radiographic survey consisting of 14 periapicals and two bitewings. The marginal bone level was measured with a digital caliper in mm, rounded off to the nearest 0.1 mm. The measurements were performed at the mesial and distal aspect of the tooth, from the cemento-enamel junction to the marginal bone. These measurements were used to calculate the marginal bone level (A) in mm for each tooth and each patient. Three thresholds were defined: normal marginal bone level (A < 3 mm), borderline marginal bone level (3 mm < or = A < 4 mm) and reduced marginal bone level (A > or = 4 mm).
Results: The prevalence of reduced marginal bone level in the individual and the frequency of teeth with reduced marginal bone level were almost similar. A reduced marginal bone level was evenly distributed among the tooth groups. Approximately 12% had reduced marginal bone level, 12% were in the borderline marginal bone level group, and the remaining 76% had a normal marginal bone level. The marginal bone level was ever more reduced with increasing age. No significant difference in bone level was observed between genders.
Conclusions: The prevalence of reduced marginal bone level in a random Danish population is approximately 12% and is comparable to findings in other European countries.
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Tissue Eng Regen Med
January 2025
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 172 Dolma-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.
Background: Traditionally, dental implants require a healing period of 4 to 9 months for osseointegration, with longer recovery times considered when bone grafting is needed. This retrospective study evaluates the clinical efficacy of demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) during dental implant placement to expedite the osseointegration period for early loading.
Methods: Thirty patients (17 male, 13 female; mean age 55.
Nat Commun
January 2025
Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, CA, 94143, USA.
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the mechanisms by which they operate are not clear. Moreover, their role in central tolerance is obscured by redundancy among the Nr4a family members and by their reported functions in Treg generation and maintenance. Here we take advantage of competitive bone marrow chimeras and the OT-II/RIPmOVA model to show that Nr4a1 and Nr4a3 are essential for the upregulation of Bcl2l11/BIM and thymic clonal deletion by self-antigen.
View Article and Find Full Text PDFClin Oral Implants Res
January 2025
Second Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Objectives: WNT10A mutations are associated with tooth agenesis. This study aimed to assess the clinical outcomes of dental implants in patients carrying WNT10A mutations with different molecular statuses and phenotypes over a long-term follow-up period.
Materials And Methods: Patients with tooth agenesis were screened by whole-exome sequencing (WES) from January 2010 to September 2023.
Am J Transl Res
December 2024
Department of Stomatology, Hongci Hospital Tangshan 063000, Hebei, China.
Objective: To evaluate the effects of tinidazole (TNZ) combined with minocycline (MINO) on therapeutic effectiveness, bone resorption, and inflammation in peri-implantitis (PI).
Methods: This retrospective study included 96 PI patients admitted between January 2023 and February 2024. Patients were divided into a control group (n = 46) treated with MINO and a research group (n = 50) treated with TNZ plus MINO.
Vet Res Commun
January 2025
Veterinary Teaching Hospital, Complutense University of Madrid, Avda. Puerta de Hierro s/n, Madrid, 28040, Spain.
This case report describes the reconstruction of a rostral maxillary defect by two custom-made titanium implants following a rostral partial maxillectomy for treatment of squamous cell carcinoma (SCC) in a seven-year-old dog. An incisional biopsy and CT scan were performed to establish the diagnosis, to plan possible surgery, and to assess the margins of the tumour. The patient had no radiographic signs of metastasis at the time of diagnosis.
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