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Efficacy and Safety of Antifibrinolytic Drugs in Pediatric Surgery: A Systematic Review.
Semin Thromb Hemost
July 2021
Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Antifibrinolytic drugs are used to reduce blood loss and subsequent transfusions during surgery and following trauma, but the optimal dosing regimen in the pediatric population is still unresolved. The aim of this systematic review was to evaluate efficacy and safety of antifibrinolytic drugs in pediatric surgery and trauma to determine the optimal dosing regimen. A literature search was performed in PubMed, Embase, Cochrane, and Web of Science on May 3, 2020.
View Article and Find Full Text PDFMulticenter International Survey on Cardiopulmonary Bypass Perfusion Practices in Adult Cardiac Surgery.
J Cardiothorac Vasc Anesth
April 2021
King's College Hospital NHS Foundation Trust, London, United Kingdom; King's College London British Heart Foundation Centre of Excellence, London, United Kingdom. Electronic address:
Objectives: To assess current practice in adult cardiac surgery during cardiopulmonary bypass (CPB) across European and non-European countries.
Design: International, multicenter, web-based survey including 28 multiple choice questions addressing hemodynamic and tissue oxygenation parameters, organ protection measures, and the monitoring and usage of anesthetic drugs as part of the anesthetic and perfusion practice during CPB.
Setting: Online survey endorsed by the European Association of Cardiothoracic Anesthesiologists.
Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin.
Biophys J
August 2020
Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria. Electronic address:
Biomolecular recognition between proteins follows complex mechanisms, the understanding of which can substantially advance drug discovery efforts. Here, we track each step of the binding process in atomistic detail with molecular dynamics simulations using trypsin and its inhibitor bovine pancreatic trypsin inhibitor (BPTI) as a model system. We use umbrella sampling to cover a range of unbinding pathways.
View Article and Find Full Text PDFUlinastatin reduces postoperative bleeding and red blood cell transfusion in patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis.
Medicine (Baltimore)
February 2020
Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing.
Background: Ulinastatin is a type of glycoprotein and a nonspecific wide-spectrum protease inhibitor like antifibrinolytic agent aprotinin. Whether Ulinastatin has similar beneficial effects on blood conservation in cardiac surgical patients as aprotinin remains undetermined. Therefore, a systematic review and meta-analysis were performed to evaluate the effects of Ulinastatin on perioperative bleeding and transfusion in patients who underwent cardiac surgery.
View Article and Find Full Text PDFAdvances in treatment of acute sulfur mustard poisoning - a critical review.
Crit Rev Toxicol
March 2019
Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand , Iran.
Sulfur mustard (SM) is a blistering chemical warfare agent that was used during the World War I and in the Iraq-Iran conflict. The aim of this paper is to discuss and critically review the published results of experiments on the treatment of SM poisoning based on our clinical and research experience. The victims must remove from the contaminated zone immediately.
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