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The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis.
J Orthop Surg Res
December 2024
School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Objective: Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.
View Article and Find Full Text PDFThere Is No Difference in Clinical Outcomes Between Early or Late Weight-Bearing After Autologous Osteochondral Transplantation for Osteochondral Lesion of the Talus: A Systematic Review.
Arthroscopy
November 2024
Department of Orthopaedic Surgery, National University Hospital, National University Health System, Singapore.
Purpose: To provide a comprehensive systematic review to determine the impact of early weight-bearing compared with late weight-bearing on the clinical outcomes of patients who underwent osteochondral lesion of the talus (OLT) and were treated with autologous osteochondral transplantation (AOT) and to review the rate of return to sports and/or activities, patient satisfaction, and complications.
Methods: A systematic review of the PubMed, Embase, and The Cochrane Library databases was performed according to the Preferred Reporting Items for Systemic Reviews and Meta-Analyses guidelines. Publications were divided into group A, in which patients were allowed early weight-bearing within the first 6 weeks, whereas group B consisted of patients who were only allowed weight-bearing after 6 weeks.
Revisiting the Cyclocephagenols via : Structural Insights and Configurational Revision.
J Nat Prod
November 2024
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.
Article Synopsis
- - The study discovered a new compound, astracondensatol A, alongside six other known derivatives from the methanol extract of roots, focusing on tetrahydropyran cycloartane-type triterpenoids.
- - Researchers used 1D and 2D-NMR spectroscopy and mass spectrometry to determine the structures of these compounds, uncovering anomalies in carbon shifts that led to a revision of the absolute configurations.
- - X-ray crystallography confirmed the absolute configuration of the new compound, highlighting that previous misassignments at C-24 may have resulted from ambiguous data and publication biases.
Scaffolds for Osteochondral Lesions of the Talus: Systematic Review and Meta-Analysis of the Last Ten Years Literature.
Bioengineering (Basel)
September 2024
Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano 1/10, 40136 Bologna, Italy.
Scaffolds are widely used devices for the treatment of osteochondral lesions of the talus (OCLT), aimed at enhancing mechanical stability and fostering chondrogenic differentiation. A systematic review and meta-analysis were performed to evaluate the safety, and clinical and radiological results of scaffolds for OCLT management. On 2 January 2024, a search was performed in four databases (PubMed, Embase, Web of Science, and Scopus), according to PRISMA guidelines.
View Article and Find Full Text PDFEffect of traditional Chinese medicine on Graves' disease: a network meta-analysis.
Front Pharmacol
August 2024
Endocrinology Department 1, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Graves' disease (GD) is the most common cause of hyperthyroidism and can affect multiple systems of the body. Currently, commonly-used treatment methods for GD have a series of shortcomings. In contrast, traditional Chinese medicine has been proven to be effective in inhibiting the progression of GD and is expected to become a key direction for the development of new drugs in the future.
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