AI Article Synopsis
- There is increasing interest in how hyaluronan interacts with inflammation, particularly in wound healing.
- The study compared hyaluronan levels and inflammation in normal healing wounds and pressure ulcers, finding that inflammation peaked at day 3 while hyaluronan showed transient peaks on days 1 and 7.
- Results indicated that pressure ulcers had significantly higher myeloperoxidase activity and lower hyaluronan levels compared to acute wounds, suggesting that inflammation may lead to increased degradation of hyaluronan during wound healing.
Article Abstract
There is growing interest in the relationship of hyaluronan and inflammation in a number of physiologic processes including wound healing. The objective of this study was to make a quantitative comparison of inflammation and hyaluronan expression in human normal healing open wounds and in pressure ulcers. Using an open dermal wound model, myeloperoxidase activity was found to peak at day 3. Hyaluronan levels showed a bimodal distribution with transient peaks occurring on days 1 and 7. Mean levels of myeloperoxidase activity in pressure ulcers were significantly higher than at any time in the acute wounds, whereas hyaluronan levels were significantly lower than at any time in the acute wounds. Levels of hyaluronidase activity increased slightly in the postwound period. Hyaluronidase activity in pressure ulcers was significantly elevated compared with the acute wounds. These results suggest a role for increased enzymatic degradation of hyaluronan as a function of inflammation during wound repair. This is the first reported quantitative examination of hyaluronan expression in human acute dermal wounds and in chronic pressure ulcers.
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| http://dx.doi.org/10.1111/j.1743-6109.2006.00119.x | DOI Listing |
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