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Cyclic Adenosine Monophosphate Signaling in Chronic Kidney Disease: Molecular Targets and Therapeutic Potentials.
Int J Mol Sci
August 2024
Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.
Chronic kidney disease (CKD) is characterized by a steady decline in kidney function and affects roughly 10% of the world's population. This review focuses on the critical function of cyclic adenosine monophosphate (cAMP) signaling in CKD, specifically how it influences both protective and pathogenic processes in the kidney. cAMP, a critical secondary messenger, controls a variety of cellular functions, including transcription, metabolism, mitochondrial homeostasis, cell proliferation, and apoptosis.
View Article and Find Full Text PDFHormonal orchestra: mastering mitochondria's role in health and disease.
Endocrine
December 2024
Universite Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, Villeurbanne, France.
Article Synopsis
- Mitochondria play a crucial role in various cellular processes, influencing stress responses, immune functions, metabolism, and cell death through mechanisms like fission, fusion, and mitophagy.
- The interaction between hormones and mitochondria affects ATP production and impacts mitochondrial composition, which is vital in processes such as apoptosis and steroid hormone biosynthesis.
- Disruptions in mitochondrial function can lead to serious health issues, including neurodegenerative diseases and cancers, while hormones can enhance mitochondrial biogenesis and offer potential therapeutic applications.
The Vasopressin Receptor Antagonist Tolvaptan Counteracts Tumor Growth in a Murine Xenograft Model of Small Cell Lung Cancer.
Int J Mol Sci
August 2024
Pituitary Diseases and Sodium Alterations Unit, AOU Careggi, 50139 Florence, Italy.
Article Synopsis
- The AVPR2 antagonist tolvaptan was shown to reduce tumor growth and increase apoptosis in small cell lung cancer using a mouse model.
- Mice treated with tolvaptan had significantly smaller tumors and better signs of survival compared to the control group.
- The treatment inhibited key signaling pathways associated with cancer progression and decreased markers linked to cell proliferation while increasing those associated with cell death.
Fisetin Treats Kidney Oxidative Stress, Inflammation, and Apoptosis in Rat Diarrhea.
Front Biosci (Schol Ed)
December 2023
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza Square, Giza, Egypt.
Background: Diarrhea is the increase in the excretion of human water; meanwhile, fisetin, a bioactive flavonol molecule, is widely used in the treatment/prevention of gastrointestinal disorders. The purpose of this study is to investigate the anti-diarrheal activity of fisetin by restoring kidney function, antioxidant activity, inflammatory markers, Na+/K+-ATPase level, apoptosis, and protein content in diarrheal rats.
Methods: A total of 36 male rats were distributed into two groups (18 rats/group): normal and diarrheal.
Vasopressin Analog [VQ]dDAVP Exerts Cooperative Anticancer Effects in Combination With Low-Dose 5-Fluorouracil on Aggressive Colorectal Cancer Models.
World J Oncol
December 2023
Center of Molecular and Translational Oncology (COMTra), Unit of Translational Oncology, Science and Technology Department, National University of Quilmes, Buenos Aires, Argentina.
Background: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Despite being an essential component of systemic chemotherapy for advanced CRC, 5-fluorouracil (5-FU) clinical use has severe limitations, such as high toxicity, low selectivity and drug resistance. [VQ]dDAVP (1-deamino-4-valine-5-glutamine-8-D-arginine vasopressin) is a peptide vasopressin analog and a selective agonist of the arginine vasopressin type 2 membrane receptor (AVPR2), expressed in microvascular and tumor tissue.
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